LINC02228

Summary

LINC02228 (long intergenic non-protein coding RNA 2228, HGNC:53097) is a long non-coding RNA gene on chromosome 5p14.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53097
Approved symbol	LINC02228
Name	long intergenic non-protein coding RNA 2228
Location	5p14.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	HIKER
Ensembl gene	ENSG00000251273
Ensembl biotype	lncRNA
OMIM	620525
Entrez	105374694
RNAcentral	URS00000EB375 — lncRNA, 534 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 13 lncRNA

ENST00000507600, ENST00000641261, ENST00000641970, ENST00000662466, ENST00000670589, ENST00000726616, ENST00000726617, ENST00000726618, ENST00000726619, ENST00000726620, ENST00000726621, ENST00000726622, ENST00000726623

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000507600 — 5 exons

Exon	Start	End
ENSE00001661086	25167162	25167191
ENSE00002025111	25136342	25136445
ENSE00002042928	25162230	25162269
ENSE00004051336	25190447	25190706
ENSE00004051343	25125746	25126454

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 85.13.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6003 / max 19.4661, expressed in 342 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
61125	0.6003	342

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.13	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.12	silver quality
placenta	UBERON:0001987	71.91	gold quality
sural nerve	UBERON:0015488	68.87	gold quality
testis	UBERON:0000473	68.72	gold quality
right testis	UBERON:0004534	68.24	gold quality
left testis	UBERON:0004533	67.98	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.34	silver quality
cortex of kidney	UBERON:0001225	58.64	gold quality
ganglionic eminence	UBERON:0004023	57.41	gold quality
skeletal muscle tissue	UBERON:0001134	56.64	gold quality
right coronary artery	UBERON:0001625	54.41	gold quality
monocyte	CL:0000576	53.96	gold quality
stromal cell of endometrium	CL:0002255	52.07	silver quality
multicellular organism	UBERON:0000468	50.70	gold quality
prefrontal cortex	UBERON:0000451	50.68	gold quality
blood	UBERON:0000178	50.49	silver quality
gall bladder	UBERON:0002110	50.38	gold quality
islet of Langerhans	UBERON:0000006	49.61	gold quality
pancreas	UBERON:0001264	49.51	gold quality
myometrium	UBERON:0001296	49.20	gold quality
calcaneal tendon	UBERON:0003701	49.20	silver quality
vermiform appendix	UBERON:0001154	48.87	gold quality
muscle of leg	UBERON:0001383	48.68	gold quality
frontal cortex	UBERON:0001870	48.37	gold quality
body of pancreas	UBERON:0001150	47.79	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	47.65	gold quality
kidney	UBERON:0002113	47.51	gold quality
gastrocnemius	UBERON:0001388	47.18	gold quality
lymph node	UBERON:0000029	46.76	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.42

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding RNA HIKER regulates erythropoiesis in Monge’s disease via CSNK2B. (PMID:37022795)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.