LINC02245

Summary

LINC02245 (long intergenic non-protein coding RNA 2245, HGNC:53134) is a long non-coding RNA gene on chromosome 2p14.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53134
Approved symbol	LINC02245
Name	long intergenic non-protein coding RNA 2245
Location	2p14
Locus type	RNA, long non-coding
Status	Approved
Aliases	lnc-SERTAD2-3, AC007386.2
Ensembl gene	ENSG00000237638
Ensembl biotype	lncRNA
Entrez	400958
RNAcentral	URS000075C780 — lncRNA, 3067 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 31 — 31 lncRNA

ENST00000449259, ENST00000653778, ENST00000659575, ENST00000666526, ENST00000669631, ENST00000685506, ENST00000693405, ENST00000771808, ENST00000771809, ENST00000771810, ENST00000771811, ENST00000771812, ENST00000771813, ENST00000771814, ENST00000771815, ENST00000771816, ENST00000771817, ENST00000771818, ENST00000771819, ENST00000771820, ENST00000771821, ENST00000771822, ENST00000771823, ENST00000771824, ENST00000771825, ENST00000771826, ENST00000771827, ENST00000771828, ENST00000771829, ENST00000771830, ENST00000771831

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000449259 — 2 exons

Exon	Start	End
ENSE00001681493	64904991	64905137
ENSE00001774306	64901840	64904620

Expression profiles

Bgee: expression breadth ubiquitous, 159 present calls, max score 86.01.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.0669 / max 86.3499, expressed in 1389 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
28793	5.7043	1385
28784	0.2127	67
28783	0.0583	22
28787	0.0364	18
28785	0.0307	17
28786	0.0217	9
28792	0.0028	1

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.01	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.90	gold quality
monocyte	CL:0000576	80.17	gold quality
leukocyte	CL:0000738	79.92	gold quality
prefrontal cortex	UBERON:0000451	79.36	gold quality
anterior cingulate cortex	UBERON:0009835	79.18	gold quality
Brodmann (1909) area 9	UBERON:0013540	79.12	gold quality
cerebellar hemisphere	UBERON:0002245	78.94	gold quality
cerebellar cortex	UBERON:0002129	78.83	gold quality
right frontal lobe	UBERON:0002810	78.83	gold quality
bone marrow cell	CL:0002092	78.45	gold quality
right hemisphere of cerebellum	UBERON:0014890	78.43	gold quality
granulocyte	CL:0000094	78.18	gold quality
spleen	UBERON:0002106	77.08	gold quality
mucosa of transverse colon	UBERON:0004991	76.55	gold quality
cerebellum	UBERON:0002037	76.14	gold quality
hypothalamus	UBERON:0001898	75.34	gold quality
hindlimb stylopod muscle	UBERON:0004252	75.12	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.98	gold quality
nucleus accumbens	UBERON:0001882	74.65	gold quality
lymph node	UBERON:0000029	74.31	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	73.86	gold quality
muscle of leg	UBERON:0001383	73.77	gold quality
gastrocnemius	UBERON:0001388	73.62	gold quality
amygdala	UBERON:0001876	73.59	gold quality
cortical plate	UBERON:0005343	73.56	gold quality
putamen	UBERON:0001874	72.99	gold quality
neocortex	UBERON:0001950	72.98	gold quality
caudate nucleus	UBERON:0001873	72.51	gold quality
frontal cortex	UBERON:0001870	72.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.07

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long Noncoding RNA SERTAD2-3 Inhibits Osteosarcoma Proliferation and Migration by Competitively Binding miR-29c. (PMID:31999493)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.