LINC02253

Summary

LINC02253 (long intergenic non-protein coding RNA 2253, HGNC:53151) is a long non-coding RNA gene on chromosome 15q26.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53151
Approved symbol	LINC02253
Name	long intergenic non-protein coding RNA 2253
Location	15q26.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000259485
Ensembl biotype	lncRNA
Entrez	107984764
RNAcentral	URS00026A1AE1 — lncRNA, 955 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 55 — 55 lncRNA

ENST00000559321, ENST00000560314, ENST00000653984, ENST00000655490, ENST00000656523, ENST00000659377, ENST00000660428, ENST00000664769, ENST00000666169, ENST00000669885, ENST00000740177, ENST00000740178, ENST00000740179, ENST00000740180, ENST00000740181, ENST00000740182, ENST00000740183, ENST00000740184, ENST00000740185, ENST00000740186, ENST00000740187, ENST00000740188, ENST00000740189, ENST00000740190, ENST00000740191, ENST00000740192, ENST00000740193, ENST00000740194, ENST00000740195, ENST00000740196, ENST00000740197, ENST00000740198, ENST00000740199, ENST00000740200, ENST00000740201, ENST00000740202, ENST00000740203, ENST00000740204, ENST00000740205, ENST00000740206, ENST00000740207, ENST00000740208, ENST00000740209, ENST00000740210, ENST00000740211, ENST00000740212, ENST00000740213, ENST00000740214, ENST00000740215, ENST00000740216, ENST00000740217, ENST00000740218, ENST00000740219, ENST00000740220, ENST00000740221

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000559321 — 6 exons

Exon	Start	End
ENSE00002555861	97411192	97411278
ENSE00002566829	97429770	97429889
ENSE00003851392	97372328	97372391
ENSE00003877472	97431791	97432086
ENSE00003878926	97236221	97236319
ENSE00003887626	97215812	97215898

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 85.18.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1040 / max 28.5267, expressed in 36 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
148775	0.0746	29
148772	0.0256	6
148774	0.0038	1

Top tissues by expression

101 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.18	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.29	gold quality
endometrium	UBERON:0001295	73.99	gold quality
ganglionic eminence	UBERON:0004023	63.56	gold quality
placenta	UBERON:0001987	61.48	gold quality
stromal cell of endometrium	CL:0002255	59.55	gold quality
testis	UBERON:0000473	56.59	gold quality
right testis	UBERON:0004534	55.68	gold quality
left testis	UBERON:0004533	54.68	gold quality
cortex of kidney	UBERON:0001225	54.36	gold quality
gall bladder	UBERON:0002110	54.29	gold quality
tibial nerve	UBERON:0001323	52.86	gold quality
uterine cervix	UBERON:0000002	51.99	gold quality
lymph node	UBERON:0000029	51.71	gold quality
body of uterus	UBERON:0009853	51.70	gold quality
blood	UBERON:0000178	51.55	gold quality
kidney	UBERON:0002113	51.20	gold quality
liver	UBERON:0002107	51.19	silver quality
endocervix	UBERON:0000458	50.17	gold quality
spleen	UBERON:0002106	49.90	gold quality
monocyte	CL:0000576	49.38	silver quality
prefrontal cortex	UBERON:0000451	49.07	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	48.00	gold quality
vermiform appendix	UBERON:0001154	47.91	gold quality
ectocervix	UBERON:0012249	47.45	gold quality
multicellular organism	UBERON:0000468	47.39	gold quality
muscle of leg	UBERON:0001383	47.04	silver quality
ovary	UBERON:0000992	46.67	gold quality
urinary bladder	UBERON:0001255	46.65	gold quality
gastrocnemius	UBERON:0001388	46.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.41

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA LINC02253 activates KRT18/MAPK/ERK pathway by mediating N6-methyladenosine modification of KRT18 mRNA in gastric cancer. (PMID:35136989)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.