LINC02263

Summary

LINC02263 (long intergenic non-protein coding RNA 2263, HGNC:53175) is a long non-coding RNA gene on chromosome 4q26.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53175
Approved symbol	LINC02263
Name	long intergenic non-protein coding RNA 2263
Location	4q26
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000228358
Entrez	105377390
RNAcentral	URS0000BC4421 — lncRNA, 583 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Bgee: expression breadth ubiquitous, 124 present calls, max score 84.05.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2606 / max 143.5361, expressed in 30 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
49411	0.1492	25
49408	0.0604	23
49410	0.0358	19
49409	0.0152	12

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
superior frontal gyrus	UBERON:0002661	84.05	gold quality
Brodmann (1909) area 9	UBERON:0013540	79.40	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	79.01	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.28	gold quality
right frontal lobe	UBERON:0002810	78.01	gold quality
frontal cortex	UBERON:0001870	76.28	gold quality
prefrontal cortex	UBERON:0000451	74.62	gold quality
primary visual cortex	UBERON:0002436	73.49	gold quality
cerebral cortex	UBERON:0000956	73.11	gold quality
anterior cingulate cortex	UBERON:0009835	71.26	gold quality
sural nerve	UBERON:0015488	70.04	gold quality
testis	UBERON:0000473	67.57	gold quality
ventricular zone	UBERON:0003053	67.49	gold quality
left testis	UBERON:0004533	66.76	gold quality
right testis	UBERON:0004534	66.43	gold quality
cortical plate	UBERON:0005343	66.12	gold quality
brain	UBERON:0000955	62.20	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	61.83	silver quality
skeletal muscle tissue	UBERON:0001134	60.76	gold quality
ganglionic eminence	UBERON:0004023	60.76	gold quality
corpus callosum	UBERON:0002336	60.44	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	59.17	gold quality
popliteal artery	UBERON:0002250	59.14	gold quality
tibial artery	UBERON:0007610	59.13	gold quality
left adrenal gland cortex	UBERON:0035825	58.37	gold quality
right coronary artery	UBERON:0001625	58.26	gold quality
lower esophagus mucosa	UBERON:0035834	58.20	gold quality
monocyte	CL:0000576	58.05	gold quality
duodenum	UBERON:0002114	57.96	gold quality
right adrenal gland cortex	UBERON:0035827	57.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.62

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000093332 (4:117369953 T>A), RS1000525626 (4:117367717 G>T), RS10006701 (4:117369113 C>T), RS1000806517 (4:117367938 T>C), RS1001009194 (4:117361809 T>C), RS1001021835 (4:117361559 C>T), RS1001086486 (4:117365525 G>A), RS1001192323 (4:117361208 A>C), RS1001691521 (4:117366904 T>C), RS1001787449 (4:117360965 C>G,T), RS10018989 (4:117369475 T>A,C,G), RS1002058599 (4:117366615 A>G), RS1002193300 (4:117369196 A>G), RS1002477675 (4:117369497 T>C), RS1002664882 (4:117367887 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Copper	affects cotreatment, decreases expression	1
Gold Compounds	increases expression	1
Okadaic Acid	decreases expression	1
Magnetite Nanoparticles	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.