LINC02270

Summary

LINC02270 (long intergenic non-protein coding RNA 2270, HGNC:53185) is a long non-coding RNA gene on chromosome 4p15.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53185
Approved symbol	LINC02270
Name	long intergenic non-protein coding RNA 2270
Location	4p15.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000251210
Ensembl biotype	lncRNA
Entrez	101929019
RNAcentral	URS00007E4BD8 — lncRNA, 672 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000505386, ENST00000515691, ENST00000657988, ENST00000667212, ENST00000667495

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000505386 — 4 exons

Exon	Start	End
ENSE00002022803	12246935	12246970
ENSE00002050017	12250987	12251286
ENSE00002058031	12243052	12243178
ENSE00003882637	12223454	12223628

Expression profiles

Bgee: expression breadth broad, 52 present calls, max score 82.82.

Top tissues by expression

168 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.82	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.58	silver quality
buccal mucosa cell	CL:0002336	75.68	gold quality
ventricular zone	UBERON:0003053	64.37	gold quality
monocyte	CL:0000576	53.90	gold quality
testis	UBERON:0000473	52.56	gold quality
left testis	UBERON:0004533	52.51	gold quality
prefrontal cortex	UBERON:0000451	51.86	gold quality
right testis	UBERON:0004534	51.31	gold quality
upper lobe of lung	UBERON:0008948	48.71	silver quality
lower lobe of lung	UBERON:0008949	48.63	silver quality
muscle of leg	UBERON:0001383	48.45	gold quality
Brodmann (1909) area 46	UBERON:0006483	48.38	gold quality
gastrocnemius	UBERON:0001388	47.30	gold quality
heart left ventricle	UBERON:0002084	47.15	gold quality
gall bladder	UBERON:0002110	46.91	gold quality
cardiac ventricle	UBERON:0002082	46.60	gold quality
upper leg skin	UBERON:0004262	46.32	silver quality
heart	UBERON:0000948	45.76	gold quality
islet of Langerhans	UBERON:0000006	45.45	silver quality
frontal cortex	UBERON:0001870	43.66	silver quality
neocortex	UBERON:0001950	43.51	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
blood	UBERON:0000178	42.77	silver quality
lung	UBERON:0002048	42.77	gold quality
right atrium auricular region	UBERON:0006631	42.63	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
anatomical system	UBERON:0000467	42.34	gold quality
cortex of kidney	UBERON:0001225	42.27	gold quality
body of stomach	UBERON:0001161	42.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.60

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.