LINC02273

Summary

LINC02273 (long intergenic non-protein coding RNA 2273, HGNC:53188) is a long non-coding RNA gene on chromosome 4q31.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53188
Approved symbol	LINC02273
Name	long intergenic non-protein coding RNA 2273
Location	4q31.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000245954
Ensembl biotype	lncRNA
Entrez	100996286
RNAcentral	URS000075D0B8 — lncRNA, 1268 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000499452, ENST00000504144, ENST00000509332, ENST00000651553, ENST00000688143, ENST00000701232, ENST00000738120, ENST00000738121, ENST00000738122, ENST00000738123

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000499452 — 3 exons

Exon	Start	End
ENSE00001966156	152101484	152101580
ENSE00001967405	152103627	152104720
ENSE00004073004	152100790	152101218

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 95.03.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.2124 / max 91.5508, expressed in 106 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
50022	0.9226	103
50023	0.1262	44
50024	0.1259	46
203377	0.0377	27

Top tissues by expression

218 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	95.03	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.05	gold quality
granulocyte	CL:0000094	79.53	gold quality
blood	UBERON:0000178	75.56	gold quality
bone marrow cell	CL:0002092	74.14	gold quality
lymph node	UBERON:0000029	72.69	gold quality
superficial temporal artery	UBERON:0001614	70.52	gold quality
vermiform appendix	UBERON:0001154	69.77	gold quality
tendon of biceps brachii	UBERON:0008188	68.54	gold quality
sperm	CL:0000019	68.41	gold quality
germinal epithelium of ovary	UBERON:0001304	63.63	gold quality
caecum	UBERON:0001153	63.39	gold quality
lower lobe of lung	UBERON:0008949	62.86	silver quality
spleen	UBERON:0002106	62.35	gold quality
bone marrow	UBERON:0002371	62.21	gold quality
oocyte	CL:0000023	62.13	gold quality
leukocyte	CL:0000738	59.93	gold quality
epithelium of nasopharynx	UBERON:0001951	59.42	gold quality
cartilage tissue	UBERON:0002418	59.21	gold quality
gall bladder	UBERON:0002110	58.26	gold quality
myocardium	UBERON:0002349	56.65	gold quality
medial globus pallidus	UBERON:0002477	56.51	gold quality
rectum	UBERON:0001052	56.05	gold quality
tonsil	UBERON:0002372	56.01	gold quality
mucosa of paranasal sinus	UBERON:0005030	55.85	gold quality
vena cava	UBERON:0004087	55.16	gold quality
jejunal mucosa	UBERON:0000399	54.89	gold quality
endothelial cell	CL:0000115	54.78	gold quality
nasal cavity epithelium	UBERON:0005384	54.74	gold quality
trabecular bone tissue	UBERON:0002483	54.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Our findings uncover a key role of LINC02273-hnRNPL-AGR2 axis in breast cancer metastasis and provide potential novel therapeutic targets for metastatic breast cancer intervention. (PMID:31856843)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.