LINC02288

Summary

LINC02288 (long intergenic non-protein coding RNA 2288, HGNC:27505) is a long non-coding RNA gene on chromosome 14q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27505
Approved symbol	LINC02288
Name	long intergenic non-protein coding RNA 2288
Location	14q24.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000246548
Ensembl biotype	lncRNA
Entrez	283575
RNAcentral	URS000075BEBC — lncRNA, 2939 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000500215, ENST00000619017, ENST00000793445, ENST00000793446, ENST00000793447, ENST00000793448, ENST00000793449, ENST00000793450, ENST00000793451, ENST00000793452, ENST00000793453, ENST00000793454, ENST00000793455, ENST00000793456, ENST00000793457, ENST00000793802

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500215 — 4 exons

Exon	Start	End
ENSE00001959162	77066071	77066194
ENSE00001972855	77059538	77059728
ENSE00001980448	77067109	77069503
ENSE00001985489	77041064	77041277

Expression profiles

Bgee: expression breadth ubiquitous, 121 present calls, max score 75.93.

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.93	gold quality
blood	UBERON:0000178	67.24	gold quality
right lung	UBERON:0002167	58.26	gold quality
right uterine tube	UBERON:0001302	55.12	gold quality
skeletal muscle tissue	UBERON:0001134	54.95	silver quality
ganglionic eminence	UBERON:0004023	54.53	silver quality
stromal cell of endometrium	CL:0002255	54.02	silver quality
cortical plate	UBERON:0005343	53.73	silver quality
leukocyte	CL:0000738	52.91	silver quality
spleen	UBERON:0002106	52.37	gold quality
bone marrow	UBERON:0002371	52.32	silver quality
hindlimb stylopod muscle	UBERON:0004252	52.31	gold quality
tonsil	UBERON:0002372	51.21	gold quality
muscle tissue	UBERON:0002385	51.06	silver quality
liver	UBERON:0002107	50.95	silver quality
fallopian tube	UBERON:0003889	50.68	gold quality
left uterine tube	UBERON:0001303	50.63	gold quality
subcutaneous adipose tissue	UBERON:0002190	50.28	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	50.25	gold quality
islet of Langerhans	UBERON:0000006	50.19	gold quality
lung	UBERON:0002048	50.09	gold quality
right lobe of liver	UBERON:0001114	49.68	silver quality
thoracic mammary gland	UBERON:0005200	49.43	gold quality
muscle of leg	UBERON:0001383	49.42	gold quality
adipose tissue	UBERON:0001013	49.17	gold quality
prefrontal cortex	UBERON:0000451	49.13	silver quality
upper lobe of left lung	UBERON:0008952	49.03	gold quality
gastrocnemius	UBERON:0001388	48.94	gold quality
myometrium	UBERON:0001296	48.77	gold quality
monocyte	CL:0000576	48.76	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.18

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC02288 promotes chondrocyte apoptosis and inflammation through miR-374a-3p targeting RTN3. (PMID:33491257)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.