LINC02308

Summary

LINC02308 (long intergenic non-protein coding RNA 2308, HGNC:53227) is a long non-coding RNA gene on chromosome 14q31.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53227
Approved symbol	LINC02308
Name	long intergenic non-protein coding RNA 2308
Location	14q31.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000258675
Ensembl biotype	lncRNA
Entrez	100506700
RNAcentral	URS000075AC0D — lncRNA, 656 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000555001, ENST00000656095, ENST00000657354, ENST00000668972, ENST00000769791, ENST00000769792

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000555001 — 3 exons

Exon	Start	End
ENSE00002444713	81441987	81442196
ENSE00002492298	81442285	81442442
ENSE00004131228	81449889	81450377

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 83.58.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0634 / max 20.1003, expressed in 22 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
144330	0.0421	17
144329	0.0213	9

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.58	gold quality
cerebellar vermis	UBERON:0004720	77.24	gold quality
hindlimb stylopod muscle	UBERON:0004252	76.61	gold quality
skeletal muscle tissue	UBERON:0001134	74.50	gold quality
muscle of leg	UBERON:0001383	72.76	gold quality
colonic epithelium	UBERON:0000397	72.08	gold quality
gastrocnemius	UBERON:0001388	71.58	gold quality
muscle tissue	UBERON:0002385	69.74	gold quality
ventricular zone	UBERON:0003053	68.59	gold quality
ganglionic eminence	UBERON:0004023	65.68	gold quality
bone marrow	UBERON:0002371	63.48	silver quality
thymus	UBERON:0002370	62.08	silver quality
calcaneal tendon	UBERON:0003701	59.87	gold quality
left ovary	UBERON:0002119	59.58	gold quality
ovary	UBERON:0000992	59.28	gold quality
lymph node	UBERON:0000029	58.04	gold quality
gall bladder	UBERON:0002110	56.14	gold quality
ectocervix	UBERON:0012249	55.68	gold quality
liver	UBERON:0002107	54.93	silver quality
apex of heart	UBERON:0002098	54.86	gold quality
prefrontal cortex	UBERON:0000451	54.22	gold quality
right ovary	UBERON:0002118	54.07	gold quality
spleen	UBERON:0002106	54.04	gold quality
monocyte	CL:0000576	53.75	gold quality
islet of Langerhans	UBERON:0000006	52.67	gold quality
right lobe of thyroid gland	UBERON:0001119	52.59	gold quality
nucleus accumbens	UBERON:0001882	51.97	gold quality
placenta	UBERON:0001987	51.83	gold quality
caudate nucleus	UBERON:0001873	51.66	gold quality
pancreas	UBERON:0001264	51.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC02308 promotes the progression of glioma through activating mTOR/AKT-signaling pathway by targeting miR-30e-3p/TM4SF1 axis. (PMID:33945031)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.