LINC02377

Summary

LINC02377 (long intergenic non-protein coding RNA 2377, HGNC:53300) is a long non-coding RNA gene on chromosome 4q28.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53300
Approved symbol	LINC02377
Name	long intergenic non-protein coding RNA 2377
Location	4q28.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000250102
Ensembl biotype	lncRNA
Entrez	105377424
RNAcentral	URS00026A23DC — lncRNA, 3256 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000500169, ENST00000505436, ENST00000652848, ENST00000654488, ENST00000654697, ENST00000663566, ENST00000749283, ENST00000749284, ENST00000749285

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500169 — 3 exons

Exon	Start	End
ENSE00002076590	131527230	131527288
ENSE00002081895	131379751	131380341
ENSE00003855296	131528060	131528246

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 88.01.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3970 / max 29.5340, expressed in 118 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
49663	0.2791	113
49664	0.1179	69

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.01	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.22	gold quality
testis	UBERON:0000473	60.87	gold quality
right testis	UBERON:0004534	59.22	gold quality
liver	UBERON:0002107	59.01	gold quality
left testis	UBERON:0004533	58.10	gold quality
ganglionic eminence	UBERON:0004023	57.49	gold quality
sural nerve	UBERON:0015488	54.69	silver quality
right uterine tube	UBERON:0001302	53.70	gold quality
monocyte	CL:0000576	52.26	gold quality
multicellular organism	UBERON:0000468	51.20	gold quality
endocervix	UBERON:0000458	51.17	gold quality
placenta	UBERON:0001987	50.77	gold quality
blood	UBERON:0000178	50.36	gold quality
islet of Langerhans	UBERON:0000006	49.82	gold quality
cortex of kidney	UBERON:0001225	49.27	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	49.09	gold quality
vagina	UBERON:0000996	48.55	silver quality
fallopian tube	UBERON:0003889	48.03	gold quality
prefrontal cortex	UBERON:0000451	47.71	gold quality
vermiform appendix	UBERON:0001154	46.83	gold quality
adult mammalian kidney	UBERON:0000082	46.31	silver quality
muscle of leg	UBERON:0001383	46.26	gold quality
gastrocnemius	UBERON:0001388	45.86	gold quality
saliva-secreting gland	UBERON:0001044	45.65	silver quality
kidney	UBERON:0002113	45.60	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	45.18	gold quality
esophagus mucosa	UBERON:0002469	44.57	silver quality
thoracic aorta	UBERON:0001515	44.54	silver quality
ascending aorta	UBERON:0001496	44.45	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.25

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.