LINC02381

Summary

LINC02381 (long intergenic non-protein coding RNA 2381, HGNC:53304) is a long non-coding RNA gene on chromosome 12q13.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53304
Approved symbol	LINC02381
Name	long intergenic non-protein coding RNA 2381
Location	12q13.13
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC400043, HMS, lncEPAT
Ensembl gene	ENSG00000250742
Ensembl biotype	lncRNA
OMIM	620723
Entrez	400043
RNAcentral	URS000075A06D — lncRNA, 1411 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000508564, ENST00000634796, ENST00000635070, ENST00000652305, ENST00000660808, ENST00000833721

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000508564 — 2 exons

Exon	Start	End
ENSE00002039177	54131990	54132843
ENSE00002087110	54126098	54126612

Expression profiles

Bgee: expression breadth ubiquitous, 201 present calls, max score 98.67.

FANTOM5 (CAGE): breadth broad, TPM avg 5.6719 / max 180.5868, expressed in 764 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
125887	3.6028	646
125885	0.9344	421
125884	0.6777	337
125886	0.4569	216

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	98.67	gold quality
body of stomach	UBERON:0001161	95.21	gold quality
stomach	UBERON:0000945	93.77	gold quality
kidney epithelium	UBERON:0004819	93.48	gold quality
epithelial cell of pancreas	CL:0000083	92.51	silver quality
germinal epithelium of ovary	UBERON:0001304	91.68	gold quality
fundus of stomach	UBERON:0001160	90.96	gold quality
sperm	CL:0000019	90.92	gold quality
right uterine tube	UBERON:0001302	90.52	gold quality
renal medulla	UBERON:0000362	90.39	gold quality
metanephros	UBERON:0000081	90.12	gold quality
metanephros cortex	UBERON:0010533	89.69	gold quality
cardia of stomach	UBERON:0001162	89.49	gold quality
tibial nerve	UBERON:0001323	89.37	gold quality
popliteal artery	UBERON:0002250	89.08	gold quality
tibial artery	UBERON:0007610	89.04	gold quality
left ovary	UBERON:0002119	88.66	gold quality
right ovary	UBERON:0002118	88.53	gold quality
mucosa of stomach	UBERON:0001199	88.47	gold quality
mammary duct	UBERON:0001765	87.94	gold quality
epithelium of mammary gland	UBERON:0003244	87.84	gold quality
adult mammalian kidney	UBERON:0000082	87.60	gold quality
superficial temporal artery	UBERON:0001614	87.26	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	87.26	gold quality
kidney	UBERON:0002113	87.04	gold quality
spinal cord	UBERON:0002240	86.92	gold quality
ovary	UBERON:0000992	86.90	gold quality
caput epididymis	UBERON:0004358	86.57	gold quality
left uterine tube	UBERON:0001303	86.09	gold quality
skin of hip	UBERON:0001554	85.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.01

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Epigenetically silenced LINC02381 functions as a tumor suppressor by regulating PI3K-Akt signaling pathway. (PMID:32092325)
• Linc02381 Exacerbates Rheumatoid Arthritis Through Adsorbing miR-590-5p and Activating the Mitogen-Activated Protein Kinase Signaling Pathway in Rheumatoid arthritis-fibroblast-like synoviocytes. (PMID:32608996)
• The lncRNA HMS recruits RNA-binding protein HuR to stabilize the 3’-UTR of HOXC10 mRNA. (PMID:34302808)
• LINC02381, a sponge of miR-21, weakens osteogenic differentiation of hUC-MSCs through KLF12-mediated Wnt4 transcriptional repression. (PMID:34778905)
• Long Intergenic Non-Protein Coding RNA 02381 Promotes the Proliferation and Invasion of Ovarian Endometrial Stromal Cells through the miR-27b-3p/CTNNB1 Axis. (PMID:35327987)
• Inhibition of ox-LDL-induced endothelial cell injury by LINC02381 knockdown through the microRNA-491-5p/transcription factor 7 axis. (PMID:36988257)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.