LINC02389

Summary

LINC02389 (long intergenic non-protein coding RNA 2389, HGNC:53316) is a long non-coding RNA gene on chromosome 12q14.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53316
Approved symbol	LINC02389
Name	long intergenic non-protein coding RNA 2389
Location	12q14.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ41278
Ensembl gene	ENSG00000255693
Ensembl biotype	lncRNA
Entrez	400046
RNAcentral	URS000075EF57 — lncRNA, 3181 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000535058, ENST00000540024, ENST00000649369, ENST00000653132, ENST00000653464, ENST00000653818, ENST00000654555, ENST00000655129, ENST00000661071, ENST00000661511, ENST00000662789, ENST00000665647, ENST00000667999, ENST00000671328, ENST00000729967, ENST00000729968, ENST00000729969

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000535058 — 3 exons

Exon	Start	End
ENSE00002272540	64900577	64900698
ENSE00004058087	64883319	64883865
ENSE00004058090	64974571	64977522

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 85.44.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1170 / max 79.4370, expressed in 39 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
126481	0.0870	32
126482	0.0300	3

Top tissues by expression

114 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.44	silver quality
primary visual cortex	UBERON:0002436	75.88	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.00	gold quality
superior frontal gyrus	UBERON:0002661	73.69	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	73.18	gold quality
cerebral cortex	UBERON:0000956	71.36	gold quality
Ammon’s horn	UBERON:0001954	71.14	gold quality
right frontal lobe	UBERON:0002810	71.05	gold quality
frontal cortex	UBERON:0001870	70.83	gold quality
prefrontal cortex	UBERON:0000451	70.50	gold quality
anterior cingulate cortex	UBERON:0009835	69.96	gold quality
tonsil	UBERON:0002372	69.79	gold quality
putamen	UBERON:0001874	69.27	gold quality
caudate nucleus	UBERON:0001873	68.61	gold quality
nucleus accumbens	UBERON:0001882	68.56	gold quality
brain	UBERON:0000955	68.01	gold quality
cerebellar hemisphere	UBERON:0002245	67.05	gold quality
cerebellar cortex	UBERON:0002129	67.03	gold quality
cerebellum	UBERON:0002037	66.84	gold quality
cortical plate	UBERON:0005343	66.73	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.63	gold quality
bone marrow cell	CL:0002092	65.12	silver quality
hypothalamus	UBERON:0001898	64.74	gold quality
amygdala	UBERON:0001876	64.62	gold quality
temporal lobe	UBERON:0001871	64.41	gold quality
ventricular zone	UBERON:0003053	62.84	gold quality
body of pancreas	UBERON:0001150	62.78	gold quality
substantia nigra	UBERON:0002038	62.36	gold quality
colonic epithelium	UBERON:0000397	60.73	silver quality
adenohypophysis	UBERON:0002196	59.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.38

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC02389/miR-7-5p Regulated Cisplatin Resistance of Non-Small-Cell Lung Cancer via Promoting Oxidative Stress. (PMID:36311891)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.