LINC02418

Summary

LINC02418 (long intergenic non-protein coding RNA 2418, HGNC:53348) is a long non-coding RNA gene on chromosome 12q24.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53348
Approved symbol	LINC02418
Name	long intergenic non-protein coding RNA 2418
Location	12q24.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000214039
Ensembl biotype	lncRNA
Entrez	100190940
RNAcentral	URS000075A1D4 — lncRNA, 3211 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 13 lncRNA

ENST00000291374, ENST00000561864, ENST00000567788, ENST00000660273, ENST00000715402, ENST00000715403, ENST00000794071, ENST00000794072, ENST00000794073, ENST00000794074, ENST00000794075, ENST00000794076, ENST00000794077

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000291374 — 3 exons

Exon	Start	End
ENSE00001528259	130035022	130037017
ENSE00001528260	130042227	130042342
ENSE00002595324	130033454	130034910

Expression profiles

Bgee: expression breadth broad, 44 present calls, max score 72.64.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2508 / max 97.7861, expressed in 30 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
134150	0.2173	28
134152	0.0196	5
134151	0.0078	5
134149	0.0060	4

Top tissues by expression

44 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	72.64	silver quality
testis	UBERON:0000473	67.86	silver quality
duodenum	UBERON:0002114	54.50	gold quality
ovary	UBERON:0000992	54.22	silver quality
right lobe of liver	UBERON:0001114	53.81	gold quality
liver	UBERON:0002107	53.80	gold quality
skin of abdomen	UBERON:0001416	53.23	gold quality
cortex of kidney	UBERON:0001225	51.25	silver quality
prefrontal cortex	UBERON:0000451	50.62	silver quality
kidney	UBERON:0002113	49.78	silver quality
esophagus mucosa	UBERON:0002469	49.29	gold quality
right hemisphere of cerebellum	UBERON:0014890	48.55	gold quality
cerebellum	UBERON:0002037	48.49	silver quality
cerebellar cortex	UBERON:0002129	48.42	silver quality
cerebellar hemisphere	UBERON:0002245	48.34	silver quality
endometrium	UBERON:0001295	48.09	gold quality
superior frontal gyrus	UBERON:0002661	47.24	silver quality
prostate gland	UBERON:0002367	47.05	gold quality
intestine	UBERON:0000160	46.83	gold quality
myometrium	UBERON:0001296	46.76	silver quality
frontal cortex	UBERON:0001870	45.81	silver quality
blood	UBERON:0000178	45.57	silver quality
primary visual cortex	UBERON:0002436	44.98	silver quality
urinary bladder	UBERON:0001255	44.65	silver quality
cerebral cortex	UBERON:0000956	44.07	silver quality
Brodmann (1909) area 9	UBERON:0013540	43.99	silver quality
brain	UBERON:0000955	43.98	gold quality
putamen	UBERON:0001874	43.96	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	43.75	silver quality
tibial artery	UBERON:0007610	43.21	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• This study provided evidence that the novel colorectal cancer-associated lncRNA LINC02418 was an oncogenic lncRNA that promoted colorectal cancer cell proliferation and inhibited cell apoptosis through the miR-1273g-3p-MELK axis. (PMID:31358735)
• LncRNA LINC02418 regulates proliferation and apoptosis of non-small cell lung cancer cells by regulating miR-4677-3p/SEC61G. (PMID:31841189)
• LINC02418 promotes malignant behaviors in lung adenocarcinoma cells by sponging miR-4677-3p to upregulate KNL1 expression. (PMID:32795273)
• LINC02418 upregulates EPHA2 by competitively sponging miR-372-3p to promote 5-Fu/DDP chemoresistance in colorectal cancer. (PMID:35914269)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.