LINC02446

Summary

LINC02446 (long intergenic non-protein coding RNA 2446, HGNC:53378) is a long non-coding RNA gene on chromosome 12p13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53378
Approved symbol	LINC02446
Name	long intergenic non-protein coding RNA 2446
Location	12p13.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000256039
Ensembl biotype	lncRNA
Entrez	101060038
RNAcentral	URS0000BC462C — lncRNA, 1597 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000544591, ENST00000652990, ENST00000702299, ENST00000702593, ENST00000718315, ENST00000732311, ENST00000732312, ENST00000732313, ENST00000732314, ENST00000732315, ENST00000732316

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000544591 — 2 exons

Exon	Start	End
ENSE00004062537	10553328	10553516
ENSE00004062546	10557336	10558801

Expression profiles

Bgee: expression breadth ubiquitous, 120 present calls, max score 80.47.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.9546 / max 314.0601, expressed in 103 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
124170	1.9439	103
124171	0.0108	3

Top tissues by expression

123 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.47	gold quality
lymph node	UBERON:0000029	79.87	gold quality
granulocyte	CL:0000094	78.96	gold quality
blood	UBERON:0000178	78.27	gold quality
colonic epithelium	UBERON:0000397	77.03	gold quality
bone marrow cell	CL:0002092	74.39	gold quality
thymus	UBERON:0002370	74.27	gold quality
vermiform appendix	UBERON:0001154	73.52	gold quality
bone marrow	UBERON:0002371	72.68	gold quality
skeletal muscle tissue	UBERON:0001134	71.26	silver quality
tonsil	UBERON:0002372	69.59	gold quality
quadriceps femoris	UBERON:0001377	69.42	gold quality
spleen	UBERON:0002106	67.95	gold quality
cerebellar vermis	UBERON:0004720	67.75	gold quality
ventricular zone	UBERON:0003053	66.69	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.10	gold quality
small intestine	UBERON:0002108	64.01	gold quality
urinary bladder	UBERON:0001255	63.38	gold quality
leukocyte	CL:0000738	63.10	gold quality
lung	UBERON:0002048	61.10	gold quality
stomach	UBERON:0000945	61.02	gold quality
body of stomach	UBERON:0001161	60.86	gold quality
rectum	UBERON:0001052	60.44	gold quality
duodenum	UBERON:0002114	60.27	gold quality
upper lobe of left lung	UBERON:0008952	60.12	gold quality
liver	UBERON:0002107	59.72	gold quality
gall bladder	UBERON:0002110	59.63	gold quality
intestine	UBERON:0000160	57.82	gold quality
right lung	UBERON:0002167	57.78	gold quality
mucosa of transverse colon	UBERON:0004991	56.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.