LINC02453

Summary

LINC02453 (long intergenic non-protein coding RNA 2453, HGNC:53392) is a long non-coding RNA gene on chromosome 12q23.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53392
Approved symbol	LINC02453
Name	long intergenic non-protein coding RNA 2453
Location	12q23.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000245017
Ensembl biotype	lncRNA
Entrez	643770
RNAcentral	URS000075C2D0 — lncRNA, 1825 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 27 lncRNA

ENST00000501499, ENST00000549004, ENST00000789930, ENST00000789931, ENST00000789932, ENST00000789933, ENST00000789934, ENST00000789935, ENST00000789936, ENST00000789937, ENST00000789938, ENST00000789939, ENST00000789940, ENST00000789941, ENST00000789942, ENST00000789943, ENST00000789944, ENST00000789945, ENST00000789946, ENST00000789947, ENST00000789948, ENST00000789949, ENST00000789950, ENST00000789951, ENST00000789952, ENST00000789953, ENST00000789954

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000501499 — 4 exons

Exon	Start	End
ENSE00001768911	98493431	98493484
ENSE00001970435	98502583	98502612
ENSE00004169701	98485544	98487188
ENSE00004169732	98503760	98503916

Expression profiles

Bgee: expression breadth ubiquitous, 124 present calls, max score 87.92.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5263 / max 41.0487, expressed in 262 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
132826	0.5263	262

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.92	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.60	gold quality
right lobe of liver	UBERON:0001114	83.33	gold quality
liver	UBERON:0002107	79.92	gold quality
left testis	UBERON:0004533	78.11	gold quality
testis	UBERON:0000473	77.98	gold quality
right testis	UBERON:0004534	77.27	gold quality
right adrenal gland cortex	UBERON:0035827	72.71	gold quality
right adrenal gland	UBERON:0001233	71.94	gold quality
left adrenal gland	UBERON:0001234	71.24	gold quality
left adrenal gland cortex	UBERON:0035825	70.96	gold quality
duodenum	UBERON:0002114	70.75	gold quality
adrenal gland	UBERON:0002369	70.43	gold quality
granulocyte	CL:0000094	68.38	gold quality
monocyte	CL:0000576	67.89	gold quality
leukocyte	CL:0000738	67.79	gold quality
ganglionic eminence	UBERON:0004023	67.65	gold quality
left ovary	UBERON:0002119	66.99	gold quality
body of pancreas	UBERON:0001150	66.58	gold quality
tonsil	UBERON:0002372	66.51	gold quality
ovary	UBERON:0000992	66.34	gold quality
adrenal tissue	UBERON:0018303	65.91	gold quality
hindlimb stylopod muscle	UBERON:0004252	65.87	gold quality
right uterine tube	UBERON:0001302	65.78	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	65.53	gold quality
primary visual cortex	UBERON:0002436	65.40	gold quality
rectum	UBERON:0001052	65.32	gold quality
mucosa of transverse colon	UBERON:0004991	65.12	gold quality
pancreas	UBERON:0001264	64.86	gold quality
ventricular zone	UBERON:0003053	64.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.23

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.