LINC02454

Summary

LINC02454 (long intergenic non-protein coding RNA 2454, HGNC:53387) is a long non-coding RNA gene on chromosome 12q14.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53387
Approved symbol	LINC02454
Name	long intergenic non-protein coding RNA 2454
Location	12q14.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000256268
Ensembl biotype	lncRNA
Entrez	105369807
RNAcentral	URS0000BC4577 — lncRNA, 611 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000539116, ENST00000541391, ENST00000657815, ENST00000670328, ENST00000799822, ENST00000799823, ENST00000799824, ENST00000799825, ENST00000799826, ENST00000799827, ENST00000799828, ENST00000799829, ENST00000799830, ENST00000799831, ENST00000799832, ENST00000799833

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000539116 — 2 exons

Exon	Start	End
ENSE00002223835	65606028	65606503
ENSE00002276486	65602869	65602981

Expression profiles

Bgee: expression breadth ubiquitous, 113 present calls, max score 74.13.

FANTOM5 (CAGE): breadth broad, TPM avg 2.3313 / max 98.0734, expressed in 700 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
126497	1.9525	645
126496	0.3788	218

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	74.13	gold quality
cortical plate	UBERON:0005343	64.09	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.99	gold quality
skeletal muscle tissue	UBERON:0001134	60.79	gold quality
gall bladder	UBERON:0002110	60.55	gold quality
islet of Langerhans	UBERON:0000006	60.53	gold quality
tonsil	UBERON:0002372	60.48	silver quality
ventricular zone	UBERON:0003053	59.54	gold quality
prefrontal cortex	UBERON:0000451	58.06	gold quality
vermiform appendix	UBERON:0001154	57.09	gold quality
pancreas	UBERON:0001264	55.95	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	55.48	gold quality
thoracic aorta	UBERON:0001515	54.81	gold quality
ascending aorta	UBERON:0001496	54.75	gold quality
endometrium	UBERON:0001295	54.24	gold quality
right coronary artery	UBERON:0001625	53.37	gold quality
tibial artery	UBERON:0007610	53.27	gold quality
superior frontal gyrus	UBERON:0002661	53.24	gold quality
popliteal artery	UBERON:0002250	53.16	gold quality
smooth muscle tissue	UBERON:0001135	52.94	gold quality
heart	UBERON:0000948	52.75	gold quality
calcaneal tendon	UBERON:0003701	52.72	silver quality
left coronary artery	UBERON:0001626	52.62	gold quality
frontal cortex	UBERON:0001870	52.62	gold quality
heart left ventricle	UBERON:0002084	52.32	gold quality
adenohypophysis	UBERON:0002196	52.15	gold quality
placenta	UBERON:0001987	52.04	gold quality
right atrium auricular region	UBERON:0006631	51.96	gold quality
urinary bladder	UBERON:0001255	51.83	gold quality
monocyte	CL:0000576	51.50	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.11

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Overexpression of novel long intergenic noncoding RNA LINC02454 is associated with a poor prognosis in papillary thyroid cancer. (PMID:32945494)
• LINC02454 promotes thyroid carcinoma progression via upregulating HMGA2 through CREB1. (PMID:37997502)
• LINC02454-CCT complex interaction is essential for telomerase activity and cell proliferation in head and neck squamous cell carcinoma. (PMID:38401886)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.