LINC02457

Summary

LINC02457 (long intergenic non-protein coding RNA 2457, HGNC:53393) is a long non-coding RNA gene on chromosome 12q24.22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53393
Approved symbol	LINC02457
Name	long intergenic non-protein coding RNA 2457
Location	12q24.22
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000258018
Ensembl biotype	lncRNA
Entrez	107984439
RNAcentral	URS0000EF4194 — lncRNA, 4898 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000552992, ENST00000659057, ENST00000739862

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000552992 — 2 exons

Exon	Start	End
ENSE00002400826	116517858	116517890
ENSE00002419316	116518258	116518820

Expression profiles

Bgee: expression breadth broad, 66 present calls, max score 69.50.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0417 / max 26.1725, expressed in 13 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
128226	0.0417	13

Top tissues by expression

66 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	69.50	silver quality
cortical plate	UBERON:0005343	67.98	gold quality
duodenum	UBERON:0002114	54.43	gold quality
bone marrow	UBERON:0002371	52.54	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	51.59	gold quality
lymph node	UBERON:0000029	51.01	gold quality
blood	UBERON:0000178	50.89	gold quality
myometrium	UBERON:0001296	50.86	gold quality
vermiform appendix	UBERON:0001154	50.53	gold quality
tonsil	UBERON:0002372	50.10	gold quality
prefrontal cortex	UBERON:0000451	49.78	gold quality
right lobe of liver	UBERON:0001114	47.33	silver quality
thoracic mammary gland	UBERON:0005200	47.15	silver quality
stomach	UBERON:0000945	47.05	gold quality
heart left ventricle	UBERON:0002084	46.34	gold quality
Brodmann (1909) area 9	UBERON:0013540	45.91	silver quality
gastrocnemius	UBERON:0001388	45.73	silver quality
right atrium auricular region	UBERON:0006631	45.22	gold quality
cerebellum	UBERON:0002037	44.97	silver quality
esophagus	UBERON:0001043	44.93	gold quality
esophagus mucosa	UBERON:0002469	44.92	gold quality
colon	UBERON:0001155	44.72	gold quality
cerebellar cortex	UBERON:0002129	44.56	silver quality
frontal cortex	UBERON:0001870	44.54	silver quality
cerebellar hemisphere	UBERON:0002245	44.50	silver quality
ovary	UBERON:0000992	44.31	gold quality
minor salivary gland	UBERON:0001830	44.22	gold quality
right hemisphere of cerebellum	UBERON:0014890	44.10	silver quality
putamen	UBERON:0001874	43.80	gold quality
endometrium	UBERON:0001295	43.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.86

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.