LINC02458

Summary

LINC02458 (long intergenic non-protein coding RNA 2458, HGNC:53394) is a long non-coding RNA gene on chromosome 12q21.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53394
Approved symbol	LINC02458
Name	long intergenic non-protein coding RNA 2458
Location	12q21.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000246363
Ensembl biotype	lncRNA
Entrez	728084
RNAcentral	URS0000759E53 — lncRNA, 2509 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 21 lncRNA

ENST00000500381, ENST00000549278, ENST00000686845, ENST00000846494, ENST00000846495, ENST00000846496, ENST00000846497, ENST00000846498, ENST00000846499, ENST00000846500, ENST00000846501, ENST00000846502, ENST00000846503, ENST00000846504, ENST00000846505, ENST00000846506, ENST00000846507, ENST00000846508, ENST00000846509, ENST00000846510, ENST00000846511

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500381 — 3 exons

Exon	Start	End
ENSE00001990176	89014692	89014868
ENSE00004274320	89019553	89019781
ENSE00004274327	89010681	89013317

Expression profiles

Bgee: expression breadth broad, 84 present calls, max score 77.94.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0918 / max 8.3006, expressed in 44 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
132413	0.0918	44

Top tissues by expression

189 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.94	gold quality
prefrontal cortex	UBERON:0000451	66.64	gold quality
Brodmann (1909) area 9	UBERON:0013540	62.07	gold quality
anterior cingulate cortex	UBERON:0009835	61.61	gold quality
monocyte	CL:0000576	60.93	gold quality
leukocyte	CL:0000738	60.54	gold quality
right hemisphere of cerebellum	UBERON:0014890	59.71	gold quality
frontal cortex	UBERON:0001870	59.42	gold quality
neocortex	UBERON:0001950	59.30	gold quality
right frontal lobe	UBERON:0002810	59.23	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	58.46	gold quality
cerebral cortex	UBERON:0000956	55.38	gold quality
cerebellar hemisphere	UBERON:0002245	55.22	gold quality
forebrain	UBERON:0001890	51.16	gold quality
brain	UBERON:0000955	50.43	gold quality
omental fat pad	UBERON:0010414	50.27	gold quality
peritoneum	UBERON:0002358	50.23	gold quality
cortex of kidney	UBERON:0001225	50.17	gold quality
islet of Langerhans	UBERON:0000006	50.12	gold quality
adipose tissue of abdominal region	UBERON:0007808	49.61	gold quality
pancreas	UBERON:0001264	49.08	gold quality
middle temporal gyrus	UBERON:0002771	49.07	gold quality
amygdala	UBERON:0001876	48.46	gold quality
blood	UBERON:0000178	48.34	gold quality
gastrocnemius	UBERON:0001388	48.06	gold quality
lymph node	UBERON:0000029	47.81	gold quality
Ammon’s horn	UBERON:0001954	46.57	gold quality
hypothalamus	UBERON:0001898	46.47	gold quality
primary visual cortex	UBERON:0002436	46.32	gold quality
adrenal gland	UBERON:0002369	46.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.26

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.