LINC02525

Summary

LINC02525 (long intergenic non-protein coding RNA 2525, HGNC:53545) is a long non-coding RNA gene on chromosome 6p25.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53545
Approved symbol	LINC02525
Name	long intergenic non-protein coding RNA 2525
Location	6p25.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	TP53LC14, lncNB1, RP1-40E16.9
Ensembl gene	ENSG00000230269
Ensembl biotype	lncRNA
OMIM	621189
Entrez	100507194
RNAcentral	URS000075C027 — lncRNA, 1472 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000425384, ENST00000435043, ENST00000656983, ENST00000814153

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000425384 — 3 exons

Exon	Start	End
ENSE00001656716	3195666	3195784
ENSE00001733925	3190827	3191230
ENSE00003862344	3182630	3183726

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 88.87.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6787 / max 115.7206, expressed in 269 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
71454	0.6787	269

Top tissues by expression

187 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.87	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.57	gold quality
nucleus accumbens	UBERON:0001882	73.03	gold quality
hypothalamus	UBERON:0001898	70.13	gold quality
putamen	UBERON:0001874	69.62	gold quality
caudate nucleus	UBERON:0001873	68.64	gold quality
cortical plate	UBERON:0005343	66.36	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.79	gold quality
ganglionic eminence	UBERON:0004023	63.67	gold quality
spinal cord	UBERON:0002240	61.65	gold quality
ventricular zone	UBERON:0003053	59.91	gold quality
amygdala	UBERON:0001876	59.23	gold quality
substantia nigra	UBERON:0002038	58.78	gold quality
prefrontal cortex	UBERON:0000451	57.99	gold quality
forebrain	UBERON:0001890	57.48	gold quality
anterior cingulate cortex	UBERON:0009835	57.29	gold quality
adenohypophysis	UBERON:0002196	57.23	gold quality
pituitary gland	UBERON:0000007	56.89	gold quality
midbrain	UBERON:0001891	56.53	gold quality
Brodmann (1909) area 9	UBERON:0013540	56.42	gold quality
brain	UBERON:0000955	56.40	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	54.27	gold quality
right frontal lobe	UBERON:0002810	53.85	gold quality
neocortex	UBERON:0001950	53.83	gold quality
calcaneal tendon	UBERON:0003701	53.75	silver quality
frontal cortex	UBERON:0001870	53.09	gold quality
cerebral cortex	UBERON:0000956	52.29	gold quality
cerebellar cortex	UBERON:0002129	51.84	gold quality
cerebellar hemisphere	UBERON:0002245	51.71	gold quality
right hemisphere of cerebellum	UBERON:0014890	51.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• This study therefore identifies lncNB1 and its binding protein RPL35 as key factors for promoting E2F1 protein synthesis, N-Myc protein stability and N-Myc-driven oncogenesis, and as therapeutic targets. (PMID:31690716)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.