LINC02527

Summary

LINC02527 (long intergenic non-protein coding RNA 2527, HGNC:53553) is a long non-coding RNA gene on chromosome 6q21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53553
Approved symbol	LINC02527
Name	long intergenic non-protein coding RNA 2527
Location	6q21
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227012
Ensembl biotype	lncRNA
Entrez	105377946
RNAcentral	URS0000BC44CF — lncRNA, 1417 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000449069, ENST00000653948, ENST00000655782, ENST00000807136

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000449069 — 2 exons

Exon	Start	End
ENSE00001727233	111900489	111901141
ENSE00001801161	111901743	111901851

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 87.32.

Top tissues by expression

71 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.32	gold quality
quadriceps femoris	UBERON:0001377	82.50	gold quality
liver	UBERON:0002107	73.05	silver quality
thoracic mammary gland	UBERON:0005200	69.92	gold quality
bone marrow	UBERON:0002371	69.87	silver quality
cerebellar vermis	UBERON:0004720	67.75	gold quality
small intestine	UBERON:0002108	67.19	silver quality
kidney	UBERON:0002113	63.96	silver quality
skeletal muscle tissue	UBERON:0001134	63.51	silver quality
right lobe of thyroid gland	UBERON:0001119	63.12	gold quality
prostate gland	UBERON:0002367	62.91	silver quality
thymus	UBERON:0002370	61.44	silver quality
skin of leg	UBERON:0001511	59.48	gold quality
placenta	UBERON:0001987	59.40	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	59.25	gold quality
lymph node	UBERON:0000029	57.80	gold quality
zone of skin	UBERON:0000014	57.62	gold quality
vagina	UBERON:0000996	56.55	gold quality
spinal cord	UBERON:0002240	56.40	gold quality
right testis	UBERON:0004534	56.35	gold quality
calcaneal tendon	UBERON:0003701	56.28	silver quality
lung	UBERON:0002048	56.23	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	55.79	gold quality
testis	UBERON:0000473	55.72	gold quality
leukocyte	CL:0000738	55.68	gold quality
left testis	UBERON:0004533	55.49	gold quality
upper lobe of left lung	UBERON:0008952	55.46	gold quality
monocyte	CL:0000576	54.73	gold quality
islet of Langerhans	UBERON:0000006	54.63	gold quality
Brodmann (1909) area 9	UBERON:0013540	54.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.63

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The expression of Linc02527 was increased in placenta and serum in Intrahepatic cholestasis of pregnancy patients. Linc02527 bond to and stabilized YBX1, then activated P21 pathway and prompted autophagy. (PMID:30250023)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.