LINC02580

Summary

LINC02580 (long intergenic non-protein coding RNA 2580, HGNC:53751) is a long non-coding RNA gene on chromosome 2p21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53751
Approved symbol	LINC02580
Name	long intergenic non-protein coding RNA 2580
Location	2p21
Locus type	RNA, long non-coding
Status	Approved
Aliases	AC093609.1
Ensembl gene	ENSG00000230587
Ensembl biotype	lncRNA
Entrez	100506047
RNAcentral	URS0000CCDFD5 — lncRNA, 712 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000434020, ENST00000654095, ENST00000661106, ENST00000663868, ENST00000670047, ENST00000702810, ENST00000705257, ENST00000716701, ENST00000716702, ENST00000716703

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000434020 — 2 exons

Exon	Start	End
ENSE00001640903	43102035	43102701
ENSE00001721433	43097695	43098040

Expression profiles

Bgee: expression breadth ubiquitous, 156 present calls, max score 82.80.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1101 / max 15.5857, expressed in 47 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
28035	0.0920	37
28032	0.0181	8

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.80	gold quality
calcaneal tendon	UBERON:0003701	78.59	gold quality
granulocyte	CL:0000094	75.19	gold quality
right atrium auricular region	UBERON:0006631	73.84	gold quality
cardiac atrium	UBERON:0002081	72.99	gold quality
descending thoracic aorta	UBERON:0002345	70.48	gold quality
bone marrow cell	CL:0002092	70.47	silver quality
left coronary artery	UBERON:0001626	69.62	gold quality
hindlimb stylopod muscle	UBERON:0004252	68.87	gold quality
right lobe of thyroid gland	UBERON:0001119	68.86	gold quality
ascending aorta	UBERON:0001496	68.75	gold quality
thoracic aorta	UBERON:0001515	68.64	gold quality
right lobe of liver	UBERON:0001114	68.54	gold quality
tibial nerve	UBERON:0001323	68.52	gold quality
left lobe of thyroid gland	UBERON:0001120	68.22	gold quality
coronary artery	UBERON:0001621	68.14	gold quality
thyroid gland	UBERON:0002046	67.82	gold quality
right coronary artery	UBERON:0001625	67.67	gold quality
aorta	UBERON:0000947	67.31	gold quality
muscle of leg	UBERON:0001383	67.22	gold quality
blood	UBERON:0000178	66.84	gold quality
colonic epithelium	UBERON:0000397	66.82	silver quality
popliteal artery	UBERON:0002250	66.59	gold quality
tibial artery	UBERON:0007610	66.59	gold quality
leukocyte	CL:0000738	66.50	gold quality
heart	UBERON:0000948	66.37	gold quality
gastrocnemius	UBERON:0001388	66.35	gold quality
tendon	UBERON:0000043	65.89	gold quality
omental fat pad	UBERON:0010414	65.88	gold quality
peritoneum	UBERON:0002358	65.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding RNA LINC02580 suppresses the invasion-metastasis cascade in hepatocellular carcinoma by targeting SRSF1. (PMID:33168192)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.