LINC02587

Summary

LINC02587 (long intergenic non-protein coding RNA 2587, HGNC:50672) is a long non-coding RNA gene on chromosome 7p21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50672
Approved symbol	LINC02587
Name	long intergenic non-protein coding RNA 2587
Location	7p21.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000229108
Ensembl biotype	lncRNA
Entrez	101927524
RNAcentral	URS000075E15D — lncRNA, 2103 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000442176, ENST00000663069, ENST00000812558, ENST00000812559, ENST00000812560

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000442176 — 2 exons

Exon	Start	End
ENSE00004211721	15688187	15688452
ENSE00004211724	15694870	15696892

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 85.73.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1042 / max 15.8222, expressed in 46 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
77314	0.1042	46

Top tissues by expression

123 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	85.73	gold quality
placenta	UBERON:0001987	81.47	gold quality
omental fat pad	UBERON:0010414	79.73	gold quality
adipose tissue	UBERON:0001013	78.03	gold quality
subcutaneous adipose tissue	UBERON:0002190	76.39	gold quality
colonic epithelium	UBERON:0000397	76.26	gold quality
apex of heart	UBERON:0002098	75.98	gold quality
heart left ventricle	UBERON:0002084	74.86	gold quality
thoracic mammary gland	UBERON:0005200	74.36	gold quality
skeletal muscle tissue	UBERON:0001134	73.44	gold quality
muscle of leg	UBERON:0001383	72.27	gold quality
tibial nerve	UBERON:0001323	71.05	gold quality
gastrocnemius	UBERON:0001388	70.74	gold quality
tibial artery	UBERON:0007610	70.26	gold quality
popliteal artery	UBERON:0002250	70.25	gold quality
heart	UBERON:0000948	69.93	gold quality
hindlimb stylopod muscle	UBERON:0004252	69.90	gold quality
sural nerve	UBERON:0015488	68.59	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.28	gold quality
lower esophagus	UBERON:0013473	66.25	gold quality
right coronary artery	UBERON:0001625	66.23	gold quality
lymph node	UBERON:0000029	65.65	gold quality
right lung	UBERON:0002167	65.22	gold quality
gall bladder	UBERON:0002110	63.45	gold quality
tonsil	UBERON:0002372	63.07	gold quality
left coronary artery	UBERON:0001626	62.88	gold quality
right atrium auricular region	UBERON:0006631	62.74	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.50	gold quality
smooth muscle tissue	UBERON:0001135	61.99	gold quality
quadriceps femoris	UBERON:0001377	61.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.26

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The promotion of cervical cancer progression by signal transducer and activator of transcription 1-induced up-regulation of lncRNA MEOX2-AS1 as a competing endogenous RNA through miR-143-3p/VDAC1 pathway. (PMID:34224325)
• DNA methylation-regulated LINC02587 inhibits ferroptosis and promotes the progression of glioma cells through the CoQ-FSP1 pathway. (PMID:37848823)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.