LINC02878

Summary

LINC02878 (long intergenic non-protein coding RNA 2878, HGNC:54524) is a long non-coding RNA gene on chromosome 8q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54524
Approved symbol	LINC02878
Name	long intergenic non-protein coding RNA 2878
Location	8q24.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	BREA2
Ensembl gene	ENSG00000181097
Ensembl biotype	lncRNA
Entrez	286076
RNAcentral	URS000075C95D — lncRNA, 1002 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000531565

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000531565 — 2 exons

Exon	Start	End
ENSE00002160792	143697939	143698413
ENSE00002242274	143696154	143697641

Expression profiles

Bgee: expression breadth ubiquitous, 126 present calls, max score 79.15.

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.15	gold quality
left testis	UBERON:0004533	67.45	gold quality
testis	UBERON:0000473	67.13	gold quality
right testis	UBERON:0004534	66.73	gold quality
spleen	UBERON:0002106	64.15	gold quality
granulocyte	CL:0000094	63.61	gold quality
right uterine tube	UBERON:0001302	62.24	gold quality
ganglionic eminence	UBERON:0004023	62.21	gold quality
lower esophagus mucosa	UBERON:0035834	61.98	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.73	silver quality
stromal cell of endometrium	CL:0002255	60.37	gold quality
mucosa of transverse colon	UBERON:0004991	60.20	gold quality
muscle tissue	UBERON:0002385	59.93	gold quality
apex of heart	UBERON:0002098	59.79	gold quality
cortical plate	UBERON:0005343	59.78	silver quality
ventricular zone	UBERON:0003053	59.61	silver quality
lymph node	UBERON:0000029	59.06	gold quality
skin of leg	UBERON:0001511	58.27	gold quality
zone of skin	UBERON:0000014	58.07	gold quality
tonsil	UBERON:0002372	57.85	gold quality
skin of abdomen	UBERON:0001416	57.79	gold quality
blood	UBERON:0000178	57.77	gold quality
lower esophagus	UBERON:0013473	57.59	gold quality
lower esophagus muscularis layer	UBERON:0035833	57.56	gold quality
metanephros cortex	UBERON:0010533	57.16	gold quality
small intestine Peyer’s patch	UBERON:0003454	56.32	gold quality
fundus of stomach	UBERON:0001160	56.25	gold quality
prostate gland	UBERON:0002367	56.19	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	55.99	gold quality
small intestine	UBERON:0002108	55.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1. (PMID:36795754)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.