LINC02905

Summary

LINC02905 (long intergenic non-protein coding RNA 2905, HGNC:32200) is a long non-coding RNA gene on chromosome 8p23.1.

At a glance

• GWAS associations: 11

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32200
Approved symbol	LINC02905
Name	long intergenic non-protein coding RNA 2905
Location	8p23.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ30972, G4DM
Entrez	606553
RNAcentral	URS0002123184 — lncRNA, 1969 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long non coding RNA, C8orf49, a novel diagnostic and prognostic biomarker, enhances PTEN/FZD4-mediated cell growth and metastasis by sponging miR-1323 in endometriosis. (PMID:37557978)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000046467 (8:11762763 A>T), RS1000078517 (8:11762897 G>A), RS1001053970 (8:11761841 A>C), RS1002059814 (8:11760904 G>A), RS1002084456 (8:11763623 C>A,T), RS1002353282 (8:11760052 C>A), RS1003093685 (8:11760034 T>A,G), RS1004087144 (8:11761141 A>C), RS1004523925 (8:11761338 C>T), RS1004930065 (8:11762771 T>C), RS1005390553 (8:11762587 A>G), RS1005503543 (8:11760041 T>A), RS1005797125 (8:11759805 C>T), RS1006803952 (8:11760900 C>T), RS1006928148 (8:11762339 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

11 associations (top):

Study	Trait	p-value
GCST005273_3	Polycystic ovary syndrome	8.000000e-10
GCST007089_4	Polycystic ovary syndrome	4.000000e-12
GCST007709_209	General factor of neuroticism	6.000000e-09
GCST010132_11	Processed meat consumption	4.000000e-10
GCST010132_14	Processed meat consumption	2.000000e-15
GCST010132_15	Processed meat consumption	1.000000e-09
GCST010142_4	Fish- and plant-related diet	2.000000e-12
GCST010142_6	Fish- and plant-related diet	3.000000e-12
GCST010142_89	Fish- and plant-related diet	4.000000e-16
GCST010142_90	Fish- and plant-related diet	7.000000e-15
GCST010703_306	Brain morphology (MOSTest)	5.000000e-26

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007660	neuroticism measurement
EFO:0008111	diet measurement
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

5 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs13273672	C8orf49, GATA4	3	2.25	1	Drugs used in alcohol dependence
rs804290	C8orf49, GATA4		0.00	0
rs11785481	C8orf49, GATA4		0.00	0
rs12458	C8orf49, GATA4		0.00	0
rs3203358	C8orf49, GATA4		0.00	0

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.