LINC02911

Summary

LINC02911 (long intergenic non-protein coding RNA 2911, HGNC:44658) is a long non-coding RNA gene on chromosome 16q12.1.

At a glance

• GWAS associations: 8

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44658
Approved symbol	LINC02911
Name	long intergenic non-protein coding RNA 2911
Location	16q12.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000261190
Entrez	388276

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 90.49.

Top tissues by expression

69 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.49	gold quality
right testis	UBERON:0004534	80.18	gold quality
left testis	UBERON:0004533	80.08	gold quality
testis	UBERON:0000473	79.39	gold quality
bone marrow	UBERON:0002371	78.20	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.89	gold quality
spinal cord	UBERON:0002240	75.48	silver quality
sural nerve	UBERON:0015488	74.67	gold quality
thymus	UBERON:0002370	74.41	silver quality
ventricular zone	UBERON:0003053	69.86	gold quality
pancreas	UBERON:0001264	69.52	silver quality
quadriceps femoris	UBERON:0001377	69.42	gold quality
skeletal muscle tissue	UBERON:0001134	68.27	gold quality
cerebellar vermis	UBERON:0004720	67.75	gold quality
multicellular organism	UBERON:0000468	64.18	gold quality
tibial nerve	UBERON:0001323	60.14	gold quality
placenta	UBERON:0001987	59.48	gold quality
duodenum	UBERON:0002114	58.79	gold quality
blood	UBERON:0000178	55.49	gold quality
muscle of leg	UBERON:0001383	55.41	gold quality
monocyte	CL:0000576	54.15	gold quality
gastrocnemius	UBERON:0001388	53.49	gold quality
kidney	UBERON:0002113	52.39	gold quality
lung	UBERON:0002048	51.85	gold quality
adult mammalian kidney	UBERON:0000082	51.40	gold quality
tibial artery	UBERON:0007610	50.79	gold quality
subcutaneous adipose tissue	UBERON:0002190	50.71	silver quality
dorsolateral prefrontal cortex	UBERON:0009834	48.61	gold quality
prefrontal cortex	UBERON:0000451	47.93	gold quality
thoracic mammary gland	UBERON:0005200	47.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.06

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000048198 (16:52005380 C>T), RS1000057686 (16:52077087 CT>C,CTT,CTTT), RS1000110672 (16:52031745 A>G), RS1000142775 (16:52005621 A>C), RS1000182592 (16:52062175 C>A,T), RS1000194383 (16:52021419 C>A), RS1000254234 (16:52016032 A>G), RS1000268833 (16:52055622 G>A), RS1000306748 (16:52055398 C>G,T), RS1000387035 (16:52019183 A>G), RS1000387713 (16:52014638 T>A,G), RS1000390676 (16:52044072 C>T), RS1000408666 (16:52039001 T>C), RS1000441887 (16:52014448 T>A), RS1000453008 (16:52031937 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST003121_16	Alcohol dependence	9.000000e-06
GCST004904_241	Body mass index	2.000000e-08
GCST006041_25	Major depressive disorder	3.000000e-07
GCST006627_98	Diastolic blood pressure	4.000000e-14
GCST007324_132	Adventurousness	9.000000e-10
GCST007576_125	Chronotype	6.000000e-09
GCST007576_402	Chronotype	4.000000e-08
GCST008839_373	Height	3.000000e-08

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0006336	diastolic blood pressure
EFO:0008579	risk-taking behaviour
EFO:0008328	chronotype measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol S	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.