LINC03033

Summary

LINC03033 (long intergenic non-protein coding RNA 3033, HGNC:44292) is a long non-coding RNA gene on chromosome 14q23.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44292
Approved symbol	LINC03033
Name	long intergenic non-protein coding RNA 3033
Location	14q23
Locus type	RNA, long non-coding
Status	Approved
Aliases	LncRNA-CAF, FLJ22447
Ensembl gene	ENSG00000232774
Ensembl biotype	lncRNA
Entrez	400221
RNAcentral	URS000075C1DA — lncRNA, 1386 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000229465, ENST00000556569, ENST00000556717

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000229465 — 5 exons

Exon	Start	End
ENSE00002222670	61570540	61570760
ENSE00002255156	61653623	61653857
ENSE00002294112	61657605	61658696
ENSE00002320941	61656803	61656853
ENSE00003756066	61650962	61651017

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 86.83.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6494 / max 103.9906, expressed in 200 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
139977	0.2787	60
139978	0.1420	41
139976	0.1219	39
139980	0.0633	21
139979	0.0434	15

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	86.83	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.85	gold quality
bone marrow cell	CL:0002092	79.29	gold quality
skeletal muscle tissue	UBERON:0001134	77.24	gold quality
tonsil	UBERON:0002372	77.17	gold quality
muscle tissue	UBERON:0002385	70.62	gold quality
bone marrow	UBERON:0002371	69.79	gold quality
cortical plate	UBERON:0005343	68.04	gold quality
stromal cell of endometrium	CL:0002255	67.06	gold quality
vermiform appendix	UBERON:0001154	66.17	gold quality
granulocyte	CL:0000094	65.76	gold quality
lung	UBERON:0002048	63.97	gold quality
upper lobe of left lung	UBERON:0008952	63.84	gold quality
endometrium	UBERON:0001295	63.73	gold quality
blood	UBERON:0000178	63.71	gold quality
liver	UBERON:0002107	63.60	gold quality
ventricular zone	UBERON:0003053	63.22	gold quality
uterine cervix	UBERON:0000002	62.88	gold quality
kidney	UBERON:0002113	62.61	gold quality
right lung	UBERON:0002167	62.36	gold quality
urinary bladder	UBERON:0001255	61.98	gold quality
ganglionic eminence	UBERON:0004023	61.59	gold quality
gall bladder	UBERON:0002110	60.33	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.22	gold quality
skin of abdomen	UBERON:0001416	60.10	gold quality
myometrium	UBERON:0001296	60.08	gold quality
adult mammalian kidney	UBERON:0000082	59.84	gold quality
thoracic mammary gland	UBERON:0005200	59.75	gold quality
saliva-secreting gland	UBERON:0001044	59.68	gold quality
minor salivary gland	UBERON:0001830	59.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.03

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• We uncovered an uncharacterized lncRNA, FLJ22447, which was remarkably up-regulated in stromal carcinoma-related fibroblasts (PMID:29346528)
• Low expression of LncRNA-CAF attributed to the high expression of HIF1A in esophageal squamous cell carcinoma and gastric cancer patients. (PMID:35040008)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.