LINCADL

Summary

LINCADL (lincRNA adipogenesis and lipogenesis associated, HGNC:53956) is a long non-coding RNA gene on chromosome 5q23.1.

This gene encodes a long noncoding RNA involved in adipocyte differentiation and fatty acid synthesis. Expression of this gene is enriched in human adipose tissue. The long noncoding RNA product of this gene has been shown to interact with cytoplasmic and nuclear proteins, and these interactions may be important in post-transcriptional regulation of lipid metabolism genes.

Source: NCBI Gene 107986443 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53956
Approved symbol	LINCADL
Name	lincRNA adipogenesis and lipogenesis associated
Location	5q23.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	linc-ADAL
Ensembl gene	ENSG00000287148
Ensembl biotype	lncRNA
Entrez	107986443
RNAcentral	URS0000D780CF — lncRNA, 523 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000666259, ENST00000723762, ENST00000723763

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000666259 — 2 exons

Exon	Start	End
ENSE00004045744	115956530	115956920
ENSE00004045747	115958429	115958604

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 97.66.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.2144 / max 227.6830, expressed in 66 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
58055	0.4418	50
58052	0.3749	46
58053	0.2959	41
58054	0.0784	26
58051	0.0234	14

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	97.66	gold quality
subcutaneous adipose tissue	UBERON:0002190	94.48	gold quality
adipose tissue	UBERON:0001013	93.59	gold quality
omental fat pad	UBERON:0010414	92.36	gold quality
thoracic mammary gland	UBERON:0005200	85.74	gold quality
hindlimb stylopod muscle	UBERON:0004252	81.00	gold quality
descending thoracic aorta	UBERON:0002345	75.92	gold quality
left coronary artery	UBERON:0001626	71.99	gold quality
rectum	UBERON:0001052	71.08	gold quality
skeletal muscle tissue	UBERON:0001134	68.04	gold quality
muscle tissue	UBERON:0002385	67.44	gold quality
tibial nerve	UBERON:0001323	64.65	gold quality
lymph node	UBERON:0000029	63.12	gold quality
calcaneal tendon	UBERON:0003701	62.55	gold quality
right coronary artery	UBERON:0001625	61.65	gold quality
sural nerve	UBERON:0015488	61.57	gold quality
urinary bladder	UBERON:0001255	61.13	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	60.75	gold quality
fundus of stomach	UBERON:0001160	59.70	gold quality
multicellular organism	UBERON:0000468	59.69	gold quality
vermiform appendix	UBERON:0001154	59.63	gold quality
monocyte	CL:0000576	58.26	gold quality
heart	UBERON:0000948	57.54	gold quality
muscle of leg	UBERON:0001383	56.42	gold quality
skin of leg	UBERON:0001511	55.62	gold quality
left ovary	UBERON:0002119	55.59	gold quality
gastrocnemius	UBERON:0001388	55.50	gold quality
saliva-secreting gland	UBERON:0001044	55.12	gold quality
right atrium auricular region	UBERON:0006631	55.09	gold quality
ovary	UBERON:0000992	54.99	gold quality

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• linc-ADAL interacts with heterogeneous nuclear ribonucleoprotein U (hnRNPU) and insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) at distinct subcellular locations to regulate adipocyte differentiation and lipogenesis. (PMID:29925637)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.