LINCMD1

Summary

LINCMD1 (long intergenic non-protein coding RNA, muscle differentiation 1, HGNC:49089) is a long non-coding RNA gene on chromosome 6p12.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49089
Approved symbol	LINCMD1
Name	long intergenic non-protein coding RNA, muscle differentiation 1
Location	6p12.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225613
Ensembl biotype	lncRNA
OMIM	614933
Entrez	101154644
RNAcentral	URS00008121C0 — lncRNA, 366 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000418518

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000418518 — 3 exons

Exon	Start	End
ENSE00001693754	52150882	52151119
ENSE00001732471	52147368	52147467
ENSE00001800328	52146814	52146937

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 84.97.

Top tissues by expression

89 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	84.97	gold quality
skeletal muscle tissue	UBERON:0001134	84.04	gold quality
muscle of leg	UBERON:0001383	82.76	gold quality
sural nerve	UBERON:0015488	82.42	gold quality
gastrocnemius	UBERON:0001388	82.20	gold quality
hindlimb stylopod muscle	UBERON:0004252	79.98	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	64.98	gold quality
calcaneal tendon	UBERON:0003701	64.40	gold quality
tonsil	UBERON:0002372	62.82	gold quality
urinary bladder	UBERON:0001255	61.21	gold quality
vermiform appendix	UBERON:0001154	58.64	gold quality
prostate gland	UBERON:0002367	58.25	gold quality
lymph node	UBERON:0000029	57.95	gold quality
monocyte	CL:0000576	56.74	gold quality
right lobe of liver	UBERON:0001114	56.03	gold quality
fundus of stomach	UBERON:0001160	56.02	gold quality
minor salivary gland	UBERON:0001830	55.44	gold quality
blood	UBERON:0000178	54.32	gold quality
smooth muscle tissue	UBERON:0001135	54.15	gold quality
multicellular organism	UBERON:0000468	54.08	gold quality
gall bladder	UBERON:0002110	53.64	gold quality
stomach	UBERON:0000945	51.45	gold quality
heart left ventricle	UBERON:0002084	51.08	gold quality
body of pancreas	UBERON:0001150	50.99	gold quality
kidney	UBERON:0002113	50.78	gold quality
fallopian tube	UBERON:0003889	49.80	gold quality
adult mammalian kidney	UBERON:0000082	49.68	gold quality
heart	UBERON:0000948	49.56	gold quality
cortex of kidney	UBERON:0001225	47.36	gold quality
right frontal lobe	UBERON:0002810	46.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.47

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Some lncRNAs and their associated protein-coding genes are closely related and may be part of a potential regulatory mechanism of uremia (PMID:23100179)
• first report of lncRNA expression patterns in human ectopic and eutopic endometrial tissue from patients with ovarian endometriosis. (PMID:24502888)
• Its oncogenic activity is partially due to its repression of p21. and it may be a potential target for HCC therapy. (PMID:27154519)
• Tenogenic differentiation of human tendon-derived stem cells induced by long non-coding RNA LINCMD1 via miR-342-3p/EGR1 axis. (PMID:37287279)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.