LINGO1-AS1

Summary

LINGO1-AS1 (LINGO1 antisense RNA 1, HGNC:27368) is a long non-coding RNA gene on chromosome 15q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27368
Approved symbol	LINGO1-AS1
Name	LINGO1 antisense RNA 1
Location	15q24.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000259666
Ensembl biotype	lncRNA
Entrez	253044
RNAcentral	URS000075EF5C — lncRNA, 1735 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000558691, ENST00000558887, ENST00000560265, ENST00000654930, ENST00000668886, ENST00000726195

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000558691 — 3 exons

Exon	Start	End
ENSE00002538105	77641764	77641957
ENSE00002540995	77646388	77646511
ENSE00002549694	77647839	77649240

Expression profiles

Bgee: expression breadth ubiquitous, 106 present calls, max score 87.87.

Top tissues by expression

203 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.87	gold quality
left testis	UBERON:0004533	80.48	gold quality
right testis	UBERON:0004534	78.53	gold quality
testis	UBERON:0000473	76.78	gold quality
sperm	CL:0000019	67.37	gold quality
cortical plate	UBERON:0005343	62.11	gold quality
ventricular zone	UBERON:0003053	57.64	silver quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	57.25	gold quality
ganglionic eminence	UBERON:0004023	56.75	silver quality
biceps brachii	UBERON:0001507	54.21	gold quality
cerebellar vermis	UBERON:0004720	54.21	gold quality
parotid gland	UBERON:0001831	53.65	gold quality
body of pancreas	UBERON:0001150	52.47	gold quality
prefrontal cortex	UBERON:0000451	52.12	gold quality
muscle of leg	UBERON:0001383	50.27	gold quality
nasal cavity epithelium	UBERON:0005384	49.92	gold quality
gall bladder	UBERON:0002110	49.42	gold quality
gastrocnemius	UBERON:0001388	49.39	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	49.30	gold quality
anterior cingulate cortex	UBERON:0009835	48.87	gold quality
right hemisphere of cerebellum	UBERON:0014890	48.74	gold quality
cerebellar cortex	UBERON:0002129	48.72	gold quality
cerebellar hemisphere	UBERON:0002245	48.65	gold quality
right coronary artery	UBERON:0001625	48.29	gold quality
amygdala	UBERON:0001876	48.16	gold quality
cerebellum	UBERON:0002037	48.12	gold quality
Brodmann (1909) area 9	UBERON:0013540	47.46	gold quality
subcutaneous adipose tissue	UBERON:0002190	47.42	gold quality
neocortex	UBERON:0001950	47.35	gold quality
bronchial epithelial cell	CL:0002328	46.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.12

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Downregulation of AC061961.2, LING01-AS1, and RP11-13E1.5 may be associated with dilated cardiomyopathy progression. (PMID:30203513)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.