LINP1

Summary

LINP1 (lncRNA in non-homologous end joining pathway 1, HGNC:53170) is a long non-coding RNA gene on chromosome 10p14.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53170
Approved symbol	LINP1
Name	lncRNA in non-homologous end joining pathway 1
Location	10p14
Locus type	RNA, long non-coding
Status	Approved
Aliases	PARROT
Ensembl gene	ENSG00000223784
Ensembl biotype	lncRNA
Entrez	108570035
RNAcentral	URS0000A76D17 — lncRNA, 838 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 39 — 39 lncRNA

ENST00000417112, ENST00000436383, ENST00000648093, ENST00000648398, ENST00000648637, ENST00000648995, ENST00000649029, ENST00000649087, ENST00000649110, ENST00000649511, ENST00000649625, ENST00000650205, ENST00000650314, ENST00000650334, ENST00000650342, ENST00000650412, ENST00000829822, ENST00000829823, ENST00000829824, ENST00000829825, ENST00000829826, ENST00000829827, ENST00000829828, ENST00000829829, ENST00000829830, ENST00000829831, ENST00000829832, ENST00000829833, ENST00000829834, ENST00000829835, ENST00000829836, ENST00000829837, ENST00000829838, ENST00000829839, ENST00000829840, ENST00000829841, ENST00000829842, ENST00000829843, ENST00000829844

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000417112 — 5 exons

Exon	Start	End
ENSE00001668396	6738357	6738966
ENSE00003832518	6709530	6709572
ENSE00003834349	6737435	6737628
ENSE00003835516	6733968	6734125
ENSE00003836982	6732730	6732967

Expression profiles

Bgee: expression breadth ubiquitous, 112 present calls, max score 86.38.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5756 / max 35.6871, expressed in 188 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
103720	0.3461	152
103719	0.2295	112
103725	0.0839	39
103724	0.0106	4

Top tissues by expression

202 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	86.38	gold quality
pancreatic ductal cell	CL:0002079	86.30	silver quality
biceps brachii	UBERON:0001507	84.69	gold quality
hindlimb stylopod muscle	UBERON:0004252	83.24	gold quality
gall bladder	UBERON:0002110	83.00	gold quality
vastus lateralis	UBERON:0001379	81.81	silver quality
skeletal muscle tissue	UBERON:0001134	81.75	gold quality
quadriceps femoris	UBERON:0001377	81.16	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	79.51	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.46	gold quality
buccal mucosa cell	CL:0002336	77.42	silver quality
deltoid	UBERON:0001476	76.86	silver quality
muscle of leg	UBERON:0001383	75.50	gold quality
apex of heart	UBERON:0002098	75.43	gold quality
tibialis anterior	UBERON:0001385	74.30	silver quality
amniotic fluid	UBERON:0000173	73.70	gold quality
gastrocnemius	UBERON:0001388	73.05	gold quality
upper arm skin	UBERON:0004263	71.53	gold quality
decidua	UBERON:0002450	69.26	gold quality
heart left ventricle	UBERON:0002084	67.22	gold quality
cardiac ventricle	UBERON:0002082	66.99	gold quality
cardiac muscle of right atrium	UBERON:0003379	66.09	gold quality
vena cava	UBERON:0004087	65.07	gold quality
cerebellar vermis	UBERON:0004720	63.63	gold quality
heart	UBERON:0000948	62.86	gold quality
tendon	UBERON:0000043	62.66	gold quality
heart right ventricle	UBERON:0002080	62.62	gold quality
esophagus squamous epithelium	UBERON:0006920	61.74	gold quality
nasal cavity epithelium	UBERON:0005384	61.15	gold quality
pharyngeal mucosa	UBERON:0000355	60.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.75

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• Using a clinically guided genetic screening approach, this study identified lncRNA in nonhomologous end joining (NHEJ) pathway 1 ), which is overexpressed in human triple-negative breast cancer. LINP1 associates with proteins in the NHEJ pathway. (PMID:27111890)
• Study uncovered that LINP1 mediates its oncogenic role in breast cancer by suppressing cell growth and metastasis. Additionally, LINP1 overexpression was found in 5-fluorouracil - and doxorubicin- resistant breast cancer cell lines and was positively associated with chemoresistance. Finally, study indicated that upregulated LINP1 expression in breast cancer was associated with an unfavorable prognosis. (PMID:29293402)
• LINP1 facilitates DSBs repair through NHEJ pathway and may thus serve as a prognostic marker and a potential target for the therapy of cervical cancer. LINP1 knockdown increases radiosensitivity of Hela S3 cells. (PMID:29527968)
• LINP1 appeared to have higher expression in breast cancer tissues than in adjacent non-tumor tissues. Increased expression of LINP1 was correlated with advanced TNM stage, more lymph node metastasis, and poorer pathological differentiation. Furthermore, clinical assay indicated that patients with high LINP1 expression had a shorter overall survival and disease-free survival compared with the low LINP1 expression group. (PMID:30575915)
• LINP1 was found to inhibit the glucose metabolism by suppressing the expression of HNF4a. LINP1 strengthened the HNF4a-AMPK/WNT5A signaling pathway involved in cell glucose metabolism modulation and AML cell survival. LINP1 promotes the malignant phenotype of AML cells and stimulates glucose metabolism. (PMID:31325181)
• Long non-coding RNA LINP1 functions as an oncogene in endometrial cancer progression by regulating the PI3K/AKT signaling pathway. (PMID:31486482)
• LncRNA LINP1 confers tamoxifen resistance and negatively regulated by ER signaling in breast cancer. (PMID:31927036)
• LINP1 promotes the progression of cervical cancer by scaffolding EZH2, LSD1, and DNMT1 to inhibit the expression of KLF2 and PRSS8. (PMID:32348690)
• STAT1-induced upregulation of lncRNA LINP1 promotes cell proliferation and inhibits apoptosis via AMPK signaling pathway in papillary thyroid cancer. (PMID:32964981)
• LncRNA LINP1 promotes malignant progression of pancreatic cancer by adsorbing microRNA-491-3p. (PMID:33015772)
• LncRNA-AK149641 regulates the secretion of tumor necrosis factor-alpha in P815 mast cells by targeting the nuclear factor-kappa B signaling pathway. (PMID:33024135)
• Mechanism of efficient double-strand break repair by a long non-coding RNA. (PMID:33045735)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.