LIPE-AS1

Summary

LIPE-AS1 (LIPE antisense RNA 1, HGNC:48589) is a long non-coding RNA gene on chromosome 19q13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48589
Approved symbol	LIPE-AS1
Name	LIPE antisense RNA 1
Location	19q13.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000213904
Ensembl biotype	lncRNA
Entrez	100996307
RNAcentral	URS000075ACDD — lncRNA, 2737 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 127 — 127 lncRNA

ENST00000457234, ENST00000593491, ENST00000593740, ENST00000594624, ENST00000594688, ENST00000596116, ENST00000597203, ENST00000599276, ENST00000661814, ENST00000685146, ENST00000685574, ENST00000689053, ENST00000701294, ENST00000702399, ENST00000750098, ENST00000750099, ENST00000750100, ENST00000750101, ENST00000750102, ENST00000750103, ENST00000750104, ENST00000750105, ENST00000750106, ENST00000750107, ENST00000750108, ENST00000750109, ENST00000750110, ENST00000750111, ENST00000750112, ENST00000750113, ENST00000750114, ENST00000750115, ENST00000750116, ENST00000750117, ENST00000750118, ENST00000750119, ENST00000750120, ENST00000750121, ENST00000750122, ENST00000750123, ENST00000750124, ENST00000750125, ENST00000750126, ENST00000750127, ENST00000750128, ENST00000750129, ENST00000750130, ENST00000750131, ENST00000750132, ENST00000750133, ENST00000750134, ENST00000750135, ENST00000750136, ENST00000750137, ENST00000750138, ENST00000750139, ENST00000750140, ENST00000750141, ENST00000750142, ENST00000750143, ENST00000750144, ENST00000750145, ENST00000750146, ENST00000750147, ENST00000750148, ENST00000750149, ENST00000750150, ENST00000750151, ENST00000750152, ENST00000750153, ENST00000750154, ENST00000750155, ENST00000750156, ENST00000750157, ENST00000750158, ENST00000750159, ENST00000750160, ENST00000750161, ENST00000750162, ENST00000750163, ENST00000750164, ENST00000750165, ENST00000750166, ENST00000750167, ENST00000750168, ENST00000750169, ENST00000750170, ENST00000750171, ENST00000750172, ENST00000750173, ENST00000750174, ENST00000750175, ENST00000750176, ENST00000750177, ENST00000750178, ENST00000750179, ENST00000750180, ENST00000750181, ENST00000750182, ENST00000750183, ENST00000750184, ENST00000750185, ENST00000750186, ENST00000750187, ENST00000750188, ENST00000750189, ENST00000750190, ENST00000750191, ENST00000750192, ENST00000750193, ENST00000750194, ENST00000750195, ENST00000750196, ENST00000750197, ENST00000750198, ENST00000750199, ENST00000750200, ENST00000750201, ENST00000750202, ENST00000750203, ENST00000750204, ENST00000750205, ENST00000750206, ENST00000750207, ENST00000750208, ENST00000750209, ENST00000750210

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000457234 — 5 exons

Exon	Start	End
ENSE00001552276	42485096	42485223
ENSE00001659001	42521992	42522098
ENSE00001681103	42424269	42425204
ENSE00001778910	42510897	42510974
ENSE00001799829	42525618	42525869

Expression profiles

Bgee: expression breadth ubiquitous, 206 present calls, max score 90.16.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.7948 / max 74.1098, expressed in 1747 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
176165	5.5890	1695
176164	2.0814	1135
176168	0.0514	27
176167	0.0323	13
176170	0.0261	7
176169	0.0145	4

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	90.16	gold quality
monocyte	CL:0000576	89.82	gold quality
leukocyte	CL:0000738	89.19	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.79	gold quality
lower esophagus mucosa	UBERON:0035834	87.75	gold quality
tendon of biceps brachii	UBERON:0008188	87.37	gold quality
pancreatic ductal cell	CL:0002079	86.38	silver quality
sural nerve	UBERON:0015488	85.29	gold quality
granulocyte	CL:0000094	85.19	gold quality
hindlimb stylopod muscle	UBERON:0004252	84.90	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.27	gold quality
colonic epithelium	UBERON:0000397	84.14	gold quality
upper arm skin	UBERON:0004263	84.01	gold quality
adenohypophysis	UBERON:0002196	83.65	gold quality
tibialis anterior	UBERON:0001385	83.36	silver quality
deltoid	UBERON:0001476	83.06	silver quality
subcutaneous adipose tissue	UBERON:0002190	82.79	gold quality
omental fat pad	UBERON:0010414	82.77	gold quality
peritoneum	UBERON:0002358	82.76	gold quality
adipose tissue of abdominal region	UBERON:0007808	82.29	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.05	gold quality
pituitary gland	UBERON:0000007	81.93	gold quality
kidney epithelium	UBERON:0004819	81.78	gold quality
cardiac muscle of right atrium	UBERON:0003379	81.30	gold quality
left ventricle myocardium	UBERON:0006566	81.30	gold quality
tendon	UBERON:0000043	81.17	gold quality
mucosa of transverse colon	UBERON:0004991	81.09	gold quality
cerebellar vermis	UBERON:0004720	80.82	gold quality
left adrenal gland cortex	UBERON:0035825	80.52	gold quality
adipose tissue	UBERON:0001013	80.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Follicular fluid-derived exosomal LncRNA LIPE-AS1 modulates steroid metabolism and survival of granulosa cells leading to oocyte maturation arrest in polycystic ovary syndrome. (PMID:38656738)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.