LITATS1

Summary

LITATS1 (lncRNA induced by TGF-beta and antagonizes TGF-beta signaling 1, HGNC:49453) is a long non-coding RNA gene on chromosome 1p34.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49453
Approved symbol	LITATS1
Name	lncRNA induced by TGF-beta and antagonizes TGF-beta signaling 1
Location	1p34.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC728431
Ensembl gene	ENSG00000233621
Ensembl biotype	lncRNA
Entrez	728431
RNAcentral	URS000075ABAD — lncRNA, 1443 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 40 — 40 lncRNA

ENST00000424989, ENST00000668045, ENST00000687858, ENST00000689160, ENST00000689210, ENST00000689916, ENST00000691215, ENST00000744092, ENST00000744093, ENST00000744094, ENST00000744095, ENST00000744096, ENST00000744097, ENST00000744098, ENST00000744099, ENST00000744100, ENST00000744101, ENST00000744102, ENST00000744103, ENST00000744104, ENST00000744105, ENST00000744106, ENST00000744107, ENST00000744108, ENST00000744109, ENST00000744110, ENST00000744111, ENST00000744112, ENST00000744113, ENST00000744114, ENST00000744115, ENST00000744116, ENST00000744117, ENST00000744118, ENST00000744119, ENST00000744120, ENST00000744121, ENST00000744122, ENST00000744123, ENST00000744124

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000424989 — 3 exons

Exon	Start	End
ENSE00001762995	37456367	37456459
ENSE00003986919	37474144	37474432
ENSE00003986920	37454872	37455912

Expression profiles

Bgee: expression breadth ubiquitous, 187 present calls, max score 80.67.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 1.9588 / max 27.9844, expressed in 1051 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
11767	1.9588	1051

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right adrenal gland cortex	UBERON:0035827	80.67	gold quality
right adrenal gland	UBERON:0001233	79.99	gold quality
left adrenal gland cortex	UBERON:0035825	79.59	gold quality
left adrenal gland	UBERON:0001234	79.47	gold quality
adrenal cortex	UBERON:0001235	78.18	gold quality
right coronary artery	UBERON:0001625	77.69	gold quality
adrenal gland	UBERON:0002369	77.32	gold quality
islet of Langerhans	UBERON:0000006	77.07	gold quality
ascending aorta	UBERON:0001496	76.96	gold quality
thoracic aorta	UBERON:0001515	76.80	gold quality
right lobe of liver	UBERON:0001114	76.51	gold quality
descending thoracic aorta	UBERON:0002345	76.33	gold quality
skin of leg	UBERON:0001511	76.20	gold quality
skin of abdomen	UBERON:0001416	76.15	gold quality
gastrocnemius	UBERON:0001388	76.14	gold quality
palpebral conjunctiva	UBERON:0001812	76.10	gold quality
muscle of leg	UBERON:0001383	75.54	gold quality
stromal cell of endometrium	CL:0002255	75.44	gold quality
gall bladder	UBERON:0002110	75.09	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.98	gold quality
zone of skin	UBERON:0000014	74.64	gold quality
left coronary artery	UBERON:0001626	74.50	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	74.34	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.33	gold quality
granulocyte	CL:0000094	74.29	gold quality
aorta	UBERON:0000947	74.23	gold quality
lower esophagus mucosa	UBERON:0035834	73.92	gold quality
apex of heart	UBERON:0002098	73.77	gold quality
right lung	UBERON:0002167	73.33	gold quality
mucosa of transverse colon	UBERON:0004991	73.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.01

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long non-coding RNA LINC01137 contributes to oral squamous cell carcinoma development and is negatively regulated by miR-22-3p. (PMID:33797737)
• LncRNA LITATS1 suppresses TGF-beta-induced EMT and cancer cell plasticity by potentiating TbetaRI degradation. (PMID:36994542)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.