LIVAR

Summary

LIVAR (liver cell viability associated lncRNA, HGNC:53130) is a long non-coding RNA gene on chromosome 18q22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53130
Approved symbol	LIVAR
Name	liver cell viability associated lncRNA
Location	18q22.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	lnc18q22.2
Ensembl gene	ENSG00000266304
Ensembl biotype	lncRNA
Entrez	102724895
RNAcentral	URS0000BC4538 — lncRNA, 1675 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000578633

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578633 — 2 exons

Exon	Start	End
ENSE00004157602	70335496	70336215
ENSE00004157603	70337214	70337337

Expression profiles

Bgee: expression breadth ubiquitous, 106 present calls, max score 86.33.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1286 / max 10.1642, expressed in 44 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
172366	0.0794	25
172365	0.0492	18

Top tissues by expression

106 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.33	gold quality
liver	UBERON:0002107	73.82	gold quality
heart left ventricle	UBERON:0002084	73.02	gold quality
sural nerve	UBERON:0015488	71.00	gold quality
hindlimb stylopod muscle	UBERON:0004252	70.94	gold quality
skeletal muscle tissue	UBERON:0001134	70.86	gold quality
right lobe of liver	UBERON:0001114	70.83	gold quality
muscle tissue	UBERON:0002385	68.20	gold quality
muscle of leg	UBERON:0001383	68.03	gold quality
apex of heart	UBERON:0002098	67.89	gold quality
heart	UBERON:0000948	67.30	gold quality
gastrocnemius	UBERON:0001388	66.79	gold quality
islet of Langerhans	UBERON:0000006	63.49	gold quality
gall bladder	UBERON:0002110	62.57	gold quality
adrenal tissue	UBERON:0018303	62.32	gold quality
placenta	UBERON:0001987	62.12	gold quality
calcaneal tendon	UBERON:0003701	60.95	gold quality
lymph node	UBERON:0000029	60.12	gold quality
stromal cell of endometrium	CL:0002255	59.35	gold quality
urinary bladder	UBERON:0001255	59.03	gold quality
bone marrow	UBERON:0002371	58.40	gold quality
metanephros cortex	UBERON:0010533	58.14	gold quality
prefrontal cortex	UBERON:0000451	57.86	gold quality
right atrium auricular region	UBERON:0006631	57.64	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	57.58	gold quality
ectocervix	UBERON:0012249	57.22	gold quality
esophagus mucosa	UBERON:0002469	56.83	gold quality
blood	UBERON:0000178	56.48	gold quality
left adrenal gland	UBERON:0001234	55.89	gold quality
monocyte	CL:0000576	55.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Unveiling the role of the KLF4/Lnc18q22.2/ULBP3 axis in the tumorigenesis and immune escape of hepatocellular carcinoma under hypoxic condition. (PMID:38780505)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.