LMAN2

Summary

LMAN2 (lectin, mannose binding 2, HGNC:16986) is a protein-coding gene on chromosome 5q35.3, encoding Vesicular integral-membrane protein VIP36 (Q12907). Plays a role as an intracellular lectin in the early secretory pathway.

This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control.

Source: NCBI Gene 10960 — RefSeq curated summary.

At a glance

• GWAS associations: 16
• Clinical variants (ClinVar): 83 total — 1 likely-pathogenic
• Druggable target: yes
• MANE Select transcript: NM_006816

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16986
Approved symbol	LMAN2
Name	lectin, mannose binding 2
Location	5q35.3
Locus type	gene with protein product
Status	Approved
Aliases	GP36B, VIP36
Ensembl gene	ENSG00000169223
Ensembl biotype	protein_coding
OMIM	609551
Entrez	10960

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 10 protein_coding, 3 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000303127, ENST00000502560, ENST00000502721, ENST00000504071, ENST00000506310, ENST00000513877, ENST00000514458, ENST00000515209, ENST00000694903, ENST00000694904, ENST00000694905, ENST00000883393, ENST00000883394, ENST00000883395, ENST00000883396

RefSeq mRNA: 1 — MANE Select: NM_006816 NM_006816

CCDS: CCDS4417

Canonical transcript exons

ENST00000303127 — 8 exons

Exon	Start	End
ENSE00001157867	177334284	177334403
ENSE00001157872	177337136	177337250
ENSE00001157915	177331567	177332246
ENSE00001157923	177351452	177351668
ENSE00003572994	177337363	177337524
ENSE00003573609	177338488	177338605
ENSE00003591233	177351173	177351291
ENSE00003629703	177337706	177337785

Expression profiles

Bgee: expression breadth ubiquitous, 286 present calls, max score 98.84.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 50.1049 / max 288.7762, expressed in 1824 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
65077	49.1767	1824
65078	0.9282	616

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	98.84	gold quality
body of pancreas	UBERON:0001150	97.95	gold quality
right lobe of liver	UBERON:0001114	97.86	gold quality
esophagus mucosa	UBERON:0002469	97.80	gold quality
granulocyte	CL:0000094	97.71	gold quality
gall bladder	UBERON:0002110	97.68	gold quality
mucosa of transverse colon	UBERON:0004991	97.66	gold quality
right lobe of thyroid gland	UBERON:0001119	97.65	gold quality
monocyte	CL:0000576	97.51	gold quality
left lobe of thyroid gland	UBERON:0001120	97.51	gold quality
endocervix	UBERON:0000458	97.49	gold quality
right testis	UBERON:0004534	97.49	gold quality
left testis	UBERON:0004533	97.37	gold quality
lower esophagus mucosa	UBERON:0035834	97.33	gold quality
thyroid gland	UBERON:0002046	97.18	gold quality
rectum	UBERON:0001052	97.17	gold quality
minor salivary gland	UBERON:0001830	97.16	gold quality
right uterine tube	UBERON:0001302	97.14	gold quality
leukocyte	CL:0000738	97.12	gold quality
islet of Langerhans	UBERON:0000006	97.10	gold quality
mononuclear cell	CL:0000842	97.07	gold quality
body of stomach	UBERON:0001161	97.01	gold quality
mouth mucosa	UBERON:0003729	96.99	gold quality
pancreas	UBERON:0001264	96.97	gold quality
upper lobe of left lung	UBERON:0008952	96.84	gold quality
ectocervix	UBERON:0012249	96.84	gold quality
right ovary	UBERON:0002118	96.70	gold quality
calcaneal tendon	UBERON:0003701	96.70	gold quality
saliva-secreting gland	UBERON:0001044	96.67	gold quality
transverse colon	UBERON:0001157	96.65	gold quality

Single-cell (SCXA)

Detected in 10 experiment(s), a significant marker in 9.

Experiment	Marker?	Max mean expression
E-CURD-88	yes	89.83
E-MTAB-9467	yes	61.23
E-HCAD-4	yes	48.64
E-CURD-122	yes	38.80
E-MTAB-8410	yes	24.66
E-HCAD-11	yes	17.19
E-CURD-46	yes	12.50
E-MTAB-10553	yes	8.21
E-GEOD-110499	no	1012.60
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

12 targeting LMAN2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-4677-5P	99.70	70.09	1940
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-510-3P	99.54	70.06	2965
HSA-MIR-199A-5P	99.51	69.71	1107
HSA-MIR-199B-5P	99.51	69.74	1098
HSA-MIR-31-5P	98.58	68.35	1239
HSA-MIR-4660	97.79	67.44	1328
HSA-MIR-3974	96.56	66.22	928

Literature-anchored findings (GeneRIF, showing 8)

• Live imaging of the canine homologous protein. (PMID:11359937)
• VIP36 interacts with molecular chaperone BiP and has a role in the quality control of secretory proteins (PMID:17586539)
• selective interaction of VIPL and VIP36 with the deglucosylated trimannose in the D1 branch of high-mannose-type oligosaccharides but with different pH dependence. (PMID:18025080)
• Results identify the glycoprotein alpha1-antitrypsin as a cargo of VIP36. (PMID:20477988)
• Interaction with VIP36 is dependent on glycosylation at the same sites that allow GC-C to fold and bind ligand. (PMID:23269669)
• data thus reveal a Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B in which CD2AP facilitates the entry and LMAN2 impedes the exit of the flux, respectively. (PMID:27765817)
• White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy. (PMID:31535203)
• Comprehensive Analysis of the Expression and Prognostic Value of LMAN2 in HER2+ Breast Cancer. (PMID:35707004)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	lman2	ENSDARG00000061854
mus_musculus	Lman2	ENSMUSG00000021484
rattus_norvegicus	Lman2	ENSRNOG00000016161
drosophila_melanogaster	CG5510	FBGN0039160
caenorhabditis_elegans		WBGENE00002071

Paralogs (3): LMAN1 (ENSG00000074695), LMAN2L (ENSG00000114988), LMAN1L (ENSG00000140506)

Protein

Protein identifiers

Vesicular integral-membrane protein VIP36 — Q12907 (reviewed: Q12907)

Alternative names: Glycoprotein GP36b, Lectin mannose-binding 2, Vesicular integral-membrane protein 36

All UniProt accessions (7): Q12907, A0A384NPY7, A0A8Q3WK65, D6RBH1, D6RBV2, D6RDX1, D6RIU4

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans.

Subcellular location. Endoplasmic reticulum-Golgi intermediate compartment membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane.

Tissue specificity. Ubiquitous.

Cofactor. Binds 2 calcium ions per subunit.

RefSeq proteins (1): NP_006807* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005052	Lectin_leg	Domain
IPR013320	ConA-like_dom_sf	Homologous_superfamily
IPR035664	VIP36_lectin	Domain
IPR051136	Intracellular_Lectin-GPT	Family

Pfam: PF03388

UniProt features (18 total): binding site 9, topological domain 2, signal peptide 1, chain 1, glycosylation site 1, disulfide bond 1, sequence conflict 1, transmembrane region 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q12907-F1	84.45	0.68

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (9): 164; 166; 190; 193; 260–262; 96; 131; 162; 164–166

Disulfide bonds (1): 202–239

Glycosylation sites (1): 183

Function

Pathways and Gene Ontology

Reactome pathways

9 pathways

ID	Pathway
R-HSA-204005	COPII-mediated vesicle transport
R-HSA-5694530	Cargo concentration in the ER
R-HSA-199977	ER to Golgi Anterograde Transport
R-HSA-199991	Membrane Trafficking
R-HSA-392499	Metabolism of proteins
R-HSA-446203	Asparagine N-linked glycosylation
R-HSA-5653656	Vesicle-mediated transport
R-HSA-597592	Post-translational protein modification
R-HSA-948021	Transport to the Golgi and subsequent modification

MSigDB gene sets: 213 (showing top): GSE45365_NK_CELL_VS_CD8_TCELL_UP, SHEPARD_BMYB_MORPHOLINO_UP, GOBP_POSITIVE_REGULATION_OF_ENDOCYTOSIS, CGGAARNGGCNG_UNKNOWN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, GOCC_CELL_SURFACE, GOBP_VESICLE_MEDIATED_TRANSPORT, REACTOME_MEMBRANE_TRAFFICKING, GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT, AACWWCAANK_UNKNOWN, GOBP_ENDOPLASMIC_RETICULUM_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT, GOCC_COATED_VESICLE, HNF4_DR1_Q3, HNF4_01

GO Biological Process (4): endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888), retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum (GO:0006890), protein transport (GO:0015031), positive regulation of phagocytosis (GO:0050766)

GO Molecular Function (5): D-mannose binding (GO:0005537), carbohydrate binding (GO:0030246), heat shock protein binding (GO:0031072), metal ion binding (GO:0046872), protein binding (GO:0005515)

GO Cellular Component (12): Golgi membrane (GO:0000139), obsolete extracellular space (GO:0005615), endoplasmic reticulum membrane (GO:0005789), endoplasmic reticulum-Golgi intermediate compartment (GO:0005793), Golgi apparatus (GO:0005794), plasma membrane (GO:0005886), cell surface (GO:0009986), COPII-coated ER to Golgi transport vesicle (GO:0030134), endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116), extracellular exosome (GO:0070062), endoplasmic reticulum (GO:0005783), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-7 pathways:

Category	Pathways
ER to Golgi Anterograde Transport	2
Membrane Trafficking	1
Transport to the Golgi and subsequent modification	1
Vesicle-mediated transport	1
Post-translational protein modification	1
Metabolism of proteins	1
Asparagine N-linked glycosylation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	4
intracellular membrane-bounded organelle	3
Golgi vesicle transport	2
binding	2
bounding membrane of organelle	2
endomembrane system	2
cellular anatomical structure	2
intercellular transport	1
intracellular transport	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
phagocytosis	1
positive regulation of endocytosis	1
regulation of phagocytosis	1
monosaccharide binding	1
protein binding	1
cation binding	1
Golgi apparatus	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
membrane	1
cell periphery	1
coated vesicle	1
endoplasmic reticulum-Golgi intermediate compartment	1
extracellular vesicle	1

Protein interactions and networks

STRING

1132 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
LMAN2	MCFD2	Q8NI22	768
LMAN2	MLEC	Q14165	628
LMAN2	MOGS	Q13724	605
LMAN2	LMAN1	P49257	518
LMAN2	CANX	P27824	502
LMAN2	SEL1L	Q9UBV2	495
LMAN2	ERGIC1	Q969X5	472
LMAN2	PRR7	Q8TB68	462
LMAN2	ERLEC1	Q96DZ1	454
LMAN2	CALR	P27797	451
LMAN2	ERGIC3	Q9Y282	445
LMAN2	ENDOD1	O94919	428
LMAN2	UGGT1	Q9NYU2	427
LMAN2	FAF2	Q96CS3	421
LMAN2	DERL2	Q9GZP9	416

IntAct

113 interactions, top by confidence:

A	B	Type	Score
CENPH	NDC80	psi-mi:“MI:0914”(association)	0.800
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
SCYL1	SEC31A	psi-mi:“MI:0914”(association)	0.710
B3GNT3	PGRMC1	psi-mi:“MI:0914”(association)	0.670
CFTR	HAX1	psi-mi:“MI:0914”(association)	0.610
SPPL2B	UQCRQ	psi-mi:“MI:0914”(association)	0.530
LMAN2	PLXNB2	psi-mi:“MI:0914”(association)	0.530
rep	AGPS	psi-mi:“MI:0914”(association)	0.530
	XPO1	psi-mi:“MI:0914”(association)	0.530
ANTXR1	POTEF	psi-mi:“MI:0914”(association)	0.530
CENPH	PSMD11	psi-mi:“MI:0914”(association)	0.530
AOC3	AOC2	psi-mi:“MI:0914”(association)	0.530
env	FLOT1	psi-mi:“MI:0914”(association)	0.460
env	PGRMC1	psi-mi:“MI:0914”(association)	0.460
GPC1	SNAP23	psi-mi:“MI:0915”(physical association)	0.400
GPC1	GANAB	psi-mi:“MI:0915”(physical association)	0.400
SUPT5H	LMAN2	psi-mi:“MI:0915”(physical association)	0.370
LMAN2	MAPK9	psi-mi:“MI:0915”(physical association)	0.370
FRAT1	LMAN2	psi-mi:“MI:0915”(physical association)	0.370
LMAN2	ATP13A2	psi-mi:“MI:0915”(physical association)	0.370
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
KSR1	FBLL1	psi-mi:“MI:0914”(association)	0.350
KSR1	DDX39A	psi-mi:“MI:0914”(association)	0.350

BioGRID (170): LMAN2 (Affinity Capture-RNA), LMAN2 (Affinity Capture-RNA), LMAN2 (Affinity Capture-MS), HEATR3 (Affinity Capture-MS), PLXNB2 (Affinity Capture-MS), CENPH (Affinity Capture-MS), GPC3 (Affinity Capture-MS), TTYH3 (Affinity Capture-MS), CACNA2D1 (Affinity Capture-MS), LMAN2 (Co-fractionation), LMAN2 (Co-fractionation), LMAN2 (Co-fractionation), NDUFS3 (Co-fractionation), TMED10 (Co-fractionation), TMED2 (Co-fractionation)

ESM2 similar proteins: A1A4K5, A8MWY0, F1QR43, O13097, O15041, O18756, O73874, P11456, P20645, P24668, P49256, P49257, P52795, P52796, P79282, Q12907, Q13822, Q14165, Q2HJD1, Q3UZV7, Q5FVQ4, Q5NVB3, Q5RCF0, Q62902, Q64610, Q659X0, Q6AY20, Q6BEA0, Q6EV76, Q6EV77, Q6GMK0, Q6INX3, Q6PCX7, Q6ZQI3, Q80UG2, Q812F8, Q8BJQ9, Q8R4K8, Q8TDX6, Q9BYC5

Diamond homologs: O94401, P49256, P59481, Q12907, Q2HJD1, Q5RCF0, Q9H0V9, P49257, Q5FB95, Q62902, Q8VCD3, Q9D0F3, Q9DBH5, Q9HAT1, Q9TU32

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
LMAN2	“up-regulates quantity by stabilization”	SERPINA1	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 141 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
R-HSA-425366	7	13.2×	3e-04
SLC transporter disorders	5	10.6×	8e-03
SLC-mediated transmembrane transport	11	6.8×	3e-04
Transport of small molecules	13	3.4×	8e-03

GO biological processes:

GO term	Partners	Fold	FDR
zinc ion transmembrane transport	5	28.5×	2e-04
intracellular zinc ion homeostasis	7	27.4×	6e-06
transport across blood-brain barrier	8	11.7×	2e-04
ERAD pathway	6	8.8×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

83 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	63
Likely benign	2
Benign	2

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
152817	GRCh38/hg38 5q35.3(chr5:177118445-177374609)x3	Likely pathogenic

SpliceAI

1846 predictions. Top by Δscore:

Variant	Effect	Δscore
5:177333628:T:TA	donor_gain	1.0000
5:177334281:CACCT:C	donor_loss	1.0000
5:177334282:A:AC	donor_gain	1.0000
5:177334282:AC:A	donor_gain	1.0000
5:177334282:ACCTT:A	donor_loss	1.0000
5:177334283:C:CC	donor_gain	1.0000
5:177334283:C:G	donor_loss	1.0000
5:177334283:CC:C	donor_gain	1.0000
5:177334283:CCT:C	donor_gain	1.0000
5:177334399:ATTGT:A	acceptor_gain	1.0000
5:177334400:TTGT:T	acceptor_gain	1.0000
5:177334401:TGT:T	acceptor_gain	1.0000
5:177334402:GT:G	acceptor_gain	1.0000
5:177334403:TC:T	acceptor_loss	1.0000
5:177334404:C:CA	acceptor_loss	1.0000
5:177334404:C:CC	acceptor_gain	1.0000
5:177334405:T:G	acceptor_loss	1.0000
5:177337132:TCA:T	donor_loss	1.0000
5:177337133:CA:C	donor_loss	1.0000
5:177337134:A:AC	donor_gain	1.0000
5:177337134:AC:A	donor_gain	1.0000
5:177337134:ACCA:A	donor_loss	1.0000
5:177337135:C:CT	donor_gain	1.0000
5:177337135:CC:C	donor_gain	1.0000
5:177337135:CCAGA:C	donor_gain	1.0000
5:177337251:CT:C	acceptor_loss	1.0000
5:177337358:CTCAC:C	donor_loss	1.0000
5:177337359:TCAC:T	donor_loss	1.0000
5:177337361:A:AC	donor_gain	1.0000
5:177337362:C:CC	donor_gain	1.0000

AlphaMissense

2350 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:177337218:C:A	W236C	1.000
5:177337218:C:G	W236C	1.000
5:177337367:A:G	L224P	1.000
5:177338587:A:G	W112R	1.000
5:177338587:A:T	W112R	1.000
5:177351222:C:G	R89P	1.000
5:177351263:C:A	W75C	1.000
5:177351263:C:G	W75C	1.000
5:177351265:A:G	W75R	1.000
5:177351265:A:T	W75R	1.000
5:177332135:C:T	G341E	0.999
5:177332148:A:G	C337R	0.999
5:177332159:C:T	G333D	0.999
5:177332160:C:G	G333R	0.999
5:177334313:G:T	P294H	0.999
5:177334386:A:G	S270P	0.999
5:177334397:T:G	H266P	0.999
5:177334398:G:C	H266D	0.999
5:177337141:A:G	L262P	0.999
5:177337156:G:T	A257D	0.999
5:177337157:C:G	A257P	0.999
5:177337160:A:G	S256P	0.999
5:177337165:C:T	G254E	0.999
5:177337166:C:A	G254W	0.999
5:177337209:G:C	C239W	0.999
5:177337210:C:G	C239S	0.999
5:177337210:C:T	C239Y	0.999
5:177337211:A:G	C239R	0.999
5:177337211:A:T	C239S	0.999
5:177337220:A:G	W236R	0.999

dbSNP variants (sampled 300 via entrez): RS1000214982 (5:177349766 C>A), RS1000474241 (5:177351622 C>A), RS1000547302 (5:177351432 T>A), RS1000750560 (5:177343723 T>C), RS1000846984 (5:177333081 G>A), RS1001054889 (5:177345120 T>C), RS1001196939 (5:177348504 T>C), RS1001245051 (5:177334628 C>G), RS1001363298 (5:177332833 G>A), RS1001541282 (5:177348628 C>A,G), RS1001670780 (5:177348097 G>A,C), RS1001944374 (5:177338248 T>C), RS1001954601 (5:177331760 GC>G), RS1001978673 (5:177342292 G>A), RS1002005685 (5:177344018 C>A,T)

Disease associations

OMIM: gene MIM:609551 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

16 associations (top):

Study	Trait	p-value
GCST000649_23	Chronic kidney disease	1.000000e-14
GCST001574_7	Activated partial thromboplastin time	6.000000e-88
GCST004601_66	Red blood cell count	9.000000e-10
GCST005038_64	Allergic disease (asthma, hay fever or eczema)	1.000000e-08
GCST005956_15	Waist-to-hip ratio adjusted for BMI	1.000000e-07
GCST005957_13	Waist-to-hip ratio adjusted for BMI (age <50)	3.000000e-07
GCST005962_42	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	1.000000e-08
GCST006585_864	Blood protein levels	6.000000e-06
GCST007485_4	Anthropometric traits	1.000000e-48
GCST007490_9	Anthropometric traits (multi-trait analysis)	5.000000e-27
GCST007725_20	Serum uric acid levels	4.000000e-08
GCST009676_5	Urinary calcium excretion	4.000000e-06
GCST010244_411	Triglyceride levels	5.000000e-10
GCST90002385_353	High light scatter reticulocyte count	5.000000e-11
GCST90002405_162	Reticulocyte count	1.000000e-10
GCST90020029_1508	Waist circumference adjusted for body mass index	3.000000e-08

EFO canonical traits (10, from GWAS)

EFO ID	Trait name
EFO:0004305	erythrocyte count
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement
EFO:0004324	body weights and measures
EFO:0004761	uric acid measurement
EFO:0004838	calcium measurement
EFO:0004530	triglyceride measurement
EFO:0007986	reticulocyte count
EFO:0007789	BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066356 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases expression, affects cotreatment, affects expression	2
Tobacco Smoke Pollution	affects expression, increases expression	2
Valproic Acid	increases expression, increases methylation	2
bisphenol F	decreases expression, affects cotreatment	1
triphenyl phosphate	affects expression	1
sodium arsenite	affects binding, increases reaction	1
manganese chloride	increases expression	1
di-n-butylphosphoric acid	affects expression	1
bisphenol B	increases expression	1
bisphenol S	decreases methylation	1
Resveratrol	affects cotreatment, increases expression	1
Benzo(a)pyrene	increases methylation	1
Dexamethasone	affects cotreatment, affects expression, decreases expression	1
Indomethacin	affects expression, decreases expression, affects cotreatment	1
Isoniazid	increases expression	1
Ivermectin	decreases expression	1
Manganese	increases expression	1
Plant Extracts	increases expression, affects cotreatment	1
Ribonucleotides	affects binding	1
Selenium	affects cotreatment, increases expression	1
Smoke	decreases expression	1
Tunicamycin	increases expression	1
Vitamin E	affects cotreatment, increases expression	1
1-Methyl-3-isobutylxanthine	decreases expression, affects cotreatment, affects expression	1
Cadmium Chloride	decreases expression	1
Copper Sulfate	decreases expression	1
Lactic Acid	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651698	Binding	Binding affinity to human LMAN2 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3A8	Abcam HEK293T LMAN2 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.