LMBR1L

Summary

LMBR1L (limb development membrane protein 1 like, HGNC:18268) is a protein-coding gene on chromosome 12q13.12, encoding Protein LMBR1L (Q6UX01). Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway.

Enables transmembrane signaling receptor activity. Involved in receptor-mediated endocytosis and signal transduction. Located in endoplasmic reticulum membrane and plasma membrane.

Source: NCBI Gene 55716 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 82 total — 2 likely-pathogenic
• MANE Select transcript: NM_018113

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18268
Approved symbol	LMBR1L
Name	limb development membrane protein 1 like
Location	12q13.12
Locus type	gene with protein product
Status	Approved
Aliases	LIMR, FLJ10494, KIAA1174
Ensembl gene	ENSG00000139636
Ensembl biotype	protein_coding
OMIM	610007
Entrez	55716

Gene structure

Transcript identifiers

Ensembl transcripts: 42 — 20 protein_coding, 11 retained_intron, 7 nonsense_mediated_decay, 4 protein_coding_CDS_not_defined

ENST00000267102, ENST00000417750, ENST00000457164, ENST00000547382, ENST00000547670, ENST00000547675, ENST00000547698, ENST00000547813, ENST00000548983, ENST00000549296, ENST00000549429, ENST00000549587, ENST00000549730, ENST00000550137, ENST00000550815, ENST00000550867, ENST00000551115, ENST00000551143, ENST00000551169, ENST00000551272, ENST00000551535, ENST00000551782, ENST00000551854, ENST00000552141, ENST00000552153, ENST00000552449, ENST00000552577, ENST00000552879, ENST00000553040, ENST00000553204, ENST00000892061, ENST00000892062, ENST00000892063, ENST00000892064, ENST00000892065, ENST00000930615, ENST00000930616, ENST00000930617, ENST00000930618, ENST00000930619, ENST00000970441, ENST00000970442

RefSeq mRNA: 11 — MANE Select: NM_018113 NM_001300750, NM_001300751, NM_001352161, NM_001352162, NM_001352163, NM_001352164, NM_001352165, NM_001352166, NM_001352167, NM_001352168, NM_018113

CCDS: CCDS73466, CCDS8780

Canonical transcript exons

ENST00000267102 — 17 exons

Exon	Start	End
ENSE00001918834	49110484	49110847
ENSE00003466132	49102120	49102196
ENSE00003476286	49097139	49097739
ENSE00003484518	49097944	49098105
ENSE00003532876	49102887	49102951
ENSE00003558521	49106961	49107045
ENSE00003560299	49105924	49105957
ENSE00003567655	49103091	49103159
ENSE00003581849	49102468	49102540
ENSE00003591489	49100388	49100454
ENSE00003602894	49104746	49104885
ENSE00003605520	49100556	49100646
ENSE00003615010	49103687	49103813
ENSE00003622790	49101472	49101549
ENSE00003631612	49101250	49101323
ENSE00003632989	49104448	49104551
ENSE00003658420	49102293	49102376

Expression profiles

Bgee: expression breadth ubiquitous, 282 present calls, max score 99.00.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 25.1012 / max 171.8694, expressed in 1811 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
130803	13.1608	1788
130804	7.8586	1697
130805	4.0818	1395

Top tissues by expression

290 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	99.00	gold quality
left testis	UBERON:0004533	98.90	gold quality
right uterine tube	UBERON:0001302	98.53	gold quality
adenohypophysis	UBERON:0002196	98.21	gold quality
mucosa of stomach	UBERON:0001199	98.17	gold quality
left ovary	UBERON:0002119	98.17	gold quality
tibial nerve	UBERON:0001323	98.06	gold quality
body of uterus	UBERON:0009853	98.06	gold quality
right hemisphere of cerebellum	UBERON:0014890	97.96	gold quality
right ovary	UBERON:0002118	97.88	gold quality
cerebellar hemisphere	UBERON:0002245	97.83	gold quality
endocervix	UBERON:0000458	97.77	gold quality
cerebellar cortex	UBERON:0002129	97.74	gold quality
pituitary gland	UBERON:0000007	97.49	gold quality
ganglionic eminence	UBERON:0004023	97.47	gold quality
muscle layer of sigmoid colon	UBERON:0035805	97.44	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	97.38	gold quality
ectocervix	UBERON:0012249	97.27	gold quality
lower esophagus muscularis layer	UBERON:0035833	97.26	gold quality
lower esophagus	UBERON:0013473	97.25	gold quality
right lung	UBERON:0002167	97.23	gold quality
descending thoracic aorta	UBERON:0002345	97.23	gold quality
left uterine tube	UBERON:0001303	97.14	gold quality
right lobe of thyroid gland	UBERON:0001119	97.13	gold quality
left lobe of thyroid gland	UBERON:0001120	97.09	gold quality
small intestine Peyer’s patch	UBERON:0003454	97.08	gold quality
cortical plate	UBERON:0005343	97.07	gold quality
granulocyte	CL:0000094	97.05	gold quality
adrenal tissue	UBERON:0018303	97.00	gold quality
apex of heart	UBERON:0002098	96.92	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9801	yes	5.77
E-ANND-3	yes	3.20
E-ENAD-17	no	301.84
E-GEOD-124858	no	22.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

32 targeting LMBR1L, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-8075	99.97	67.20	962
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-1827	99.63	68.57	3265
HSA-MIR-24-3P	99.59	69.97	1934
HSA-MIR-4316	99.37	65.75	1360
HSA-MIR-149-5P	99.25	67.16	1315
HSA-MIR-544B	99.18	67.41	1632
HSA-MIR-4292	99.16	65.57	1767
HSA-MIR-6791-5P	99.16	65.92	1844
HSA-MIR-491-3P	98.88	68.86	1224
HSA-MIR-1910-3P	98.44	67.51	1695
HSA-MIR-4717-5P	98.19	67.97	894
HSA-MIR-6511A-5P	98.13	67.47	1770
HSA-MIR-450B-3P	97.56	66.12	512
HSA-MIR-96-3P	97.47	68.03	839
HSA-MIR-4640-5P	97.42	66.33	1543
HSA-MIR-4726-5P	97.24	65.67	1299

Literature-anchored findings (GeneRIF, showing 6)

• LIMR mediating internalization of lipocalin-1 (Lcn-1) in NT2 cells, leading to its degradation. (PMID:12591932)
• Human LIMR, known to act as an endocytic receptor for lipocalin-1, also binds bovine BLG and mediates its cellular uptake. (PMID:17991420)
• The receptor to which lipocalin binds is termed tear lipocalin-interacting membrane receptor and it appears to work by endocytosis. (PMID:21791187)
• LIMR was shown to be highly specific for Lcn1, binding the lipocalin with low micromolar to high nanomolar affinity (PMID:23964685)
• LMBR1L has an essential function during lymphopoiesis and lymphoid activation, acting as a negative regulator of the Wnt/beta-catenin pathway. (PMID:31073040)
• LMBR1L regulates the proliferation and migration of endothelial cells through Norrin/beta-catenin signaling. (PMID:35146515)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	lmbr1l	ENSDARG00000004745
mus_musculus	Lmbr1l	ENSMUSG00000022999
rattus_norvegicus	Lmbr1l	ENSRNOG00000061607
drosophila_melanogaster	lili	FBGN0027539
caenorhabditis_elegans		WBGENE00019877

Paralogs (1): LMBR1 (ENSG00000105983)

Protein

Protein identifiers

Protein LMBR1L — Q6UX01 (reviewed: Q6UX01)

Alternative names: Limb region 1 protein homolog-like, Lipocalin-1-interacting membrane receptor

All UniProt accessions (15): A0A024R0Y9, A0A0S2Z6E3, E7ESX7, Q6UX01, F8VPB1, F8VVE2, F8VYZ9, F8VZU8, F8W054, F8W0N6, F8WE63, H0YHY8, H0YHZ2, H0YI83, H0YIX2

UniProt curated annotations — full annotation on UniProt →

Function. Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway. In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6. LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels. Acts as a LCN1 receptor and can mediate its endocytosis.

Subunit / interactions. Dimer. Can also form higher oligomers. Interacts with LCN1; this interaction mediates the endocytosis of LCN1. Interacts with UBAC2, FAF2, VCP, AMFR, ZNRF3, CTNNB1, LRP6, GSK3A and GSK3B. Interacts with DVL2 and RNF43. Interaction with SCGB1A1 has been observed in PubMed:16423471, but not in PubMed:23964685. Interaction with LGB which mediates the endocytosis of LGB has been observed in PubMed:17991420, but not in PubMed:23964685.

Subcellular location. Cell membrane. Endoplasmic reticulum membrane.

Tissue specificity. Expressed in testis, pituitary gland, adrenal gland, trachea, placenta, thymus, cerebellum, stomach, mammary gland, spinal cord. A weaker expression is detected in colon, pancreas, and prostate.

Similarity. Belongs to the LIMR family.

Isoforms (5)

UniProt ID	Names	Canonical?
Q6UX01-1	1	yes
Q6UX01-2	2
Q6UX01-3	3
Q6UX01-4	4
Q6UX01-5	5

RefSeq proteins (11): NP_001287679, NP_001287680, NP_001339090, NP_001339091, NP_001339092, NP_001339093, NP_001339094, NP_001339095, NP_001339096, NP_001339097, NP_060583* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006876	LMBR1-like_membr_prot	Family
IPR008075	LIMR	Family

Pfam: PF04791

UniProt features (33 total): topological domain 10, transmembrane region 9, sequence conflict 6, splice variant 5, region of interest 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6UX01-F1	80.66	0.32

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 146 (showing top): GOBP_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_REGULATION_OF_WNT_SIGNALING_PATHWAY, GOBP_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION, GOBP_LEUKOCYTE_PROLIFERATION, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP, GOBP_CANONICAL_WNT_SIGNALING_PATHWAY, ROZANOV_MMP14_TARGETS_UP, BLALOCK_ALZHEIMERS_DISEASE_UP, MARTIN_VIRAL_GPCR_SIGNALING_DN, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN, GOBP_LEUKOCYTE_APOPTOTIC_PROCESS, TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P, GOBP_STEM_CELL_DIFFERENTIATION

GO Biological Process (9): receptor-mediated endocytosis (GO:0006898), signal transduction (GO:0007165), Wnt signaling pathway (GO:0016055), T cell differentiation (GO:0030217), T cell proliferation (GO:0042098), hematopoietic stem cell differentiation (GO:0060218), T cell apoptotic process (GO:0070231), negative regulation of canonical Wnt signaling pathway (GO:0090090), endocytosis (GO:0006897)

GO Molecular Function (2): transmembrane signaling receptor activity (GO:0004888), protein binding (GO:0005515)

GO Cellular Component (5): endoplasmic reticulum membrane (GO:0005789), plasma membrane (GO:0005886), endoplasmic reticulum (GO:0005783), endomembrane system (GO:0012505), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
T cell activation	2
cellular anatomical structure	2
endocytosis	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
cell surface receptor signaling pathway	1
lymphocyte differentiation	1
lymphocyte proliferation	1
hematopoietic progenitor cell differentiation	1
stem cell differentiation	1
lymphocyte apoptotic process	1
negative regulation of Wnt signaling pathway	1
canonical Wnt signaling pathway	1
regulation of canonical Wnt signaling pathway	1
vesicle budding from membrane	1
membrane invagination	1
vesicle-mediated transport	1
import into cell	1
signaling receptor activity	1
binding	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
membrane	1
cell periphery	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
vacuole	1
plasma membrane	1

Protein interactions and networks

STRING

2396 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
LMBR1L	LCN1	P31025	946
LMBR1L	D6RE68	D6RE68	700
LMBR1L	AHRR	A9YTQ3	674
LMBR1L	FAM81A	Q8TBF8	503
LMBR1L	DNAJC22	Q8N4W6	490
LMBR1L	PTPN20	Q4JDL3	472
LMBR1L	HTR5A	P47898	433
LMBR1L	LMBRD1	Q9NUN5	421
LMBR1L	FKBP10	Q96AY3	418
LMBR1L	KCNK10	P57789	415
LMBR1L	FBXL20	Q96IG2	406
LMBR1L	TOR2A	Q5JU69	404
LMBR1L	GRIN3A	Q8TCU5	403
LMBR1L	GSTCD	Q8NEC7	402
LMBR1L	KMT2E	Q8IZD2	401

IntAct

10 interactions, top by confidence:

A	B	Type	Score
CFTR	LMBR1L	psi-mi:“MI:0915”(physical association)	0.370
ECE1	LMBR1L	psi-mi:“MI:0915”(physical association)	0.370
CREB3	LMBR1L	psi-mi:“MI:0915”(physical association)	0.370
CHRNA4	TMEM223	psi-mi:“MI:0914”(association)	0.350
SLC19A2	TMEM223	psi-mi:“MI:0914”(association)	0.350
TCTN2	TMEM120B	psi-mi:“MI:2364”(proximity)	0.270
TCTN3	TMEM120B	psi-mi:“MI:2364”(proximity)	0.270
EVC2	PGRMC2	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (955): LMBR1L (Proximity Label-MS), LMBR1L (Proximity Label-MS), LMBR1L (Proximity Label-MS), LMBR1L (Two-hybrid), LMBR1L (Affinity Capture-MS), MAGEA11 (Two-hybrid), LMBR1L (Affinity Capture-Western), LMBR1L (Affinity Capture-Western), LMBR1L (Affinity Capture-Western), LMBR1L (Affinity Capture-Western), LMBR1L (Affinity Capture-Western), LMBR1L (Affinity Capture-Western), LMBR1L (Affinity Capture-Western), SRPRB (Affinity Capture-MS), SRP68 (Affinity Capture-MS)

ESM2 similar proteins: A1A4P6, A1A5B4, A5PK40, A6NDV4, A6NFX1, A6NGC4, A6QL84, A6QLK4, B1AWJ5, B6ID01, E1BY51, P58749, Q2TA01, Q2YDG0, Q32PG7, Q3T9M1, Q4R7X9, Q5HZE5, Q5JZQ7, Q5R6H1, Q5RBY7, Q60HE8, Q6AY05, Q6AYM9, Q6PHN7, Q6TCG5, Q6UX01, Q6UXD7, Q7RTT9, Q7Z403, Q80ZE4, Q8CE47, Q8R139, Q8TBR7, Q96FZ5, Q96HE8, Q96S97, Q9BSA9, Q9BZW5, Q9CQC4

Diamond homologs: Q4R7X9, Q5RBY7, Q5U4X7, Q6UX01, Q7ZUA6, Q7ZX75, Q803C7, Q8WVP7, Q9D1E5, Q9JIT0, Q9VC35

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

82 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	2
Uncertain significance	65
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
1285608	NM_018113.4(LMBR1L):c.863G>A (p.Arg288Gln)	Likely pathogenic
1285609	NM_018113.4(LMBR1L):c.862C>T (p.Arg288Trp)	Likely pathogenic

SpliceAI

2559 predictions. Top by Δscore:

Variant	Effect	Δscore
12:49097935:C:CA	donor_gain	1.0000
12:49101529:C:CT	acceptor_gain	1.0000
12:49102192:CTTCT:C	acceptor_gain	1.0000
12:49102195:CT:C	acceptor_gain	1.0000
12:49102197:C:CC	acceptor_gain	1.0000
12:49102464:TTA:T	donor_loss	1.0000
12:49102465:TACTA:T	donor_loss	1.0000
12:49102466:A:AC	donor_gain	1.0000
12:49102466:A:C	donor_loss	1.0000
12:49102467:C:CA	donor_gain	1.0000
12:49102467:CT:C	donor_gain	1.0000
12:49102467:CTA:C	donor_gain	1.0000
12:49102467:CTACA:C	donor_gain	1.0000
12:49102536:AGCAG:A	acceptor_gain	1.0000
12:49102537:GCAG:G	acceptor_gain	1.0000
12:49102538:CAG:C	acceptor_gain	1.0000
12:49102538:CAGC:C	acceptor_gain	1.0000
12:49102539:AG:A	acceptor_gain	1.0000
12:49102539:AGCT:A	acceptor_loss	1.0000
12:49102540:GCTAG:G	acceptor_loss	1.0000
12:49102541:C:CC	acceptor_gain	1.0000
12:49102541:C:T	acceptor_loss	1.0000
12:49102548:C:CT	acceptor_gain	1.0000
12:49102549:A:T	acceptor_gain	1.0000
12:49102948:CACA:C	acceptor_gain	1.0000
12:49102950:CA:C	acceptor_gain	1.0000
12:49102952:C:CC	acceptor_gain	1.0000
12:49103089:AC:A	donor_gain	1.0000
12:49103090:CC:C	donor_gain	1.0000
12:49103157:AGTCT:A	acceptor_loss	1.0000

AlphaMissense

3113 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:49102920:G:C	F221L	0.999
12:49102920:G:T	F221L	0.999
12:49102922:A:G	F221L	0.999
12:49102937:C:G	G216R	0.999
12:49100419:G:C	S403R	0.998
12:49100419:G:T	S403R	0.998
12:49100421:T:G	S403R	0.998
12:49100621:C:G	G370R	0.998
12:49102937:C:A	G216C	0.998
12:49103109:C:G	G205R	0.998
12:49103109:C:T	G205R	0.998
12:49104770:A:G	W103R	0.998
12:49104770:A:T	W103R	0.998
12:49098017:A:C	F443L	0.997
12:49098017:A:T	F443L	0.997
12:49098019:A:G	F443L	0.997
12:49100620:C:T	G370D	0.997
12:49102936:C:T	G216D	0.997
12:49104546:A:G	W113R	0.997
12:49104546:A:T	W113R	0.997
12:49102942:G:C	P214R	0.996
12:49102942:G:T	P214Q	0.996
12:49104497:G:C	P129R	0.996
12:49104768:C:A	W103C	0.996
12:49104768:C:G	W103C	0.996
12:49104813:G:C	S88R	0.996
12:49104813:G:T	S88R	0.996
12:49104815:T:G	S88R	0.996
12:49104829:G:C	P83R	0.996
12:49104873:G:C	C68W	0.996

dbSNP variants (sampled 300 via entrez): RS1000146181 (12:49098649 A>G), RS1000322578 (12:49111531 G>A), RS1000760827 (12:49097402 G>C), RS1000815726 (12:49109990 C>T), RS1000866048 (12:49099823 C>T), RS1000931238 (12:49110224 A>G,T), RS1001102807 (12:49103929 G>A), RS1001146620 (12:49100164 G>A,C), RS1001379480 (12:49112542 G>A), RS1001767551 (12:49106200 A>C,G), RS1002360574 (12:49107695 C>A), RS1002528613 (12:49100280 A>G), RS1002769063 (12:49100038 G>A), RS1002819262 (12:49112370 CCG>C), RS1003155772 (12:49103243 G>A,C)

Disease associations

OMIM: gene MIM:610007 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST008103_109	Bipolar disorder	4.000000e-06
GCST010703_9	Brain morphology (MOSTest)	8.000000e-10
GCST010989_40	Body size at age 10	9.000000e-19

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004346	neuroimaging measurement
EFO:0009819	comparative body size at age 10, self-reported

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

18 total (human), top 18 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, decreases methylation, increases expression, decreases expression	3
bisphenol F	affects cotreatment, decreases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
sodium arsenite	increases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
abrine	increases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Air Pollutants	affects expression, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Dexamethasone	affects cotreatment, decreases expression	1
Indomethacin	decreases expression, affects cotreatment	1
Ozone	affects expression, increases abundance	1
Smoke	decreases expression	1
Tretinoin	increases expression	1
Urethane	increases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, decreases expression	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E2B6	HAP1 LMBR1L (-) 1	Cancer cell line	Male
CVCL_E2B7	HAP1 LMBR1L (-) 2	Cancer cell line	Male
CVCL_E2B8	HAP1 LMBR1L (-) 3	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.