LMCD1-AS1

Summary

LMCD1-AS1 (LMCD1 antisense RNA 1, HGNC:44477) is a long non-coding RNA gene on chromosome 3p26.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44477
Approved symbol	LMCD1-AS1
Name	LMCD1 antisense RNA 1
Location	3p26.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227110
Ensembl biotype	lncRNA
Entrez	100288428
RNAcentral	URS000075EC96 — lncRNA, 2147 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000420095, ENST00000437047, ENST00000439407, ENST00000441861, ENST00000446281, ENST00000452802, ENST00000455811, ENST00000458666, ENST00000654635, ENST00000656911, ENST00000659617, ENST00000723944, ENST00000723945, ENST00000723946, ENST00000819959, ENST00000819960, ENST00000819961

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000420095 — 4 exons

Exon	Start	End
ENSE00001657192	8220683	8222719
ENSE00001702332	8494681	8494766
ENSE00001730877	8498550	8498849
ENSE00003887052	8501471	8501668

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 86.33.

FANTOM5 (CAGE): breadth broad, TPM avg 1.4841 / max 108.5483, expressed in 561 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
40927	1.4841	561

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	86.33	gold quality
sural nerve	UBERON:0015488	78.89	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.64	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	76.15	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	74.97	gold quality
substantia nigra	UBERON:0002038	70.91	gold quality
calcaneal tendon	UBERON:0003701	68.83	gold quality
colonic epithelium	UBERON:0000397	68.50	gold quality
ventricular zone	UBERON:0003053	67.72	gold quality
Ammon’s horn	UBERON:0001954	66.61	gold quality
bone marrow cell	CL:0002092	66.04	silver quality
amygdala	UBERON:0001876	66.04	gold quality
temporal lobe	UBERON:0001871	66.00	gold quality
hypothalamus	UBERON:0001898	65.04	gold quality
ganglionic eminence	UBERON:0004023	64.94	gold quality
primary visual cortex	UBERON:0002436	64.67	gold quality
skeletal muscle tissue	UBERON:0001134	64.43	gold quality
superior frontal gyrus	UBERON:0002661	64.42	gold quality
prefrontal cortex	UBERON:0000451	64.17	gold quality
putamen	UBERON:0001874	63.62	gold quality
cerebral cortex	UBERON:0000956	62.42	gold quality
frontal cortex	UBERON:0001870	62.35	gold quality
tonsil	UBERON:0002372	62.25	gold quality
islet of Langerhans	UBERON:0000006	62.01	gold quality
tibial nerve	UBERON:0001323	61.93	gold quality
nucleus accumbens	UBERON:0001882	61.86	gold quality
anterior cingulate cortex	UBERON:0009835	61.79	gold quality
brain	UBERON:0000955	61.73	gold quality
caudate nucleus	UBERON:0001873	61.71	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.13

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• E2F1 could bind directly to the promoter region of LMCD1-AS1 and activate its transcription. (PMID:30876691)
• lncRNA LMCD1-AS1 functions as a molecular sponge of let-7g to post-transcriptionally induce the target gene of let-7g, namely, P4HA2 (PMID:31278071)
• SP1-mediated upregulation of lncRNA LMCD1-AS1 functions a ceRNA for miR-106b-5p to facilitate osteosarcoma progression. (PMID:32248969)
• LMCD1-AS1 Facilitates Cell Proliferation and EMT by Sponging miR-873-3p in Cervical Cancer. (PMID:36734854)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.