LNC-LBCS

Summary

LNC-LBCS (lncRNA bladder and prostate cancer suppressor, hnRNPK interacting, HGNC:54418) is a long non-coding RNA gene on chromosome 6p22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54418
Approved symbol	LNC-LBCS
Name	lncRNA bladder and prostate cancer suppressor, hnRNPK interacting
Location	6p22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	LBCS
Ensembl gene	ENSG00000228412
Ensembl biotype	lncRNA
Entrez	100506885
RNAcentral	URS0000A76871 — lncRNA, 1940 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 53 — 53 lncRNA

ENST00000424083, ENST00000432171, ENST00000445568, ENST00000447250, ENST00000450310, ENST00000457670, ENST00000606628, ENST00000607233, ENST00000607810, ENST00000636202, ENST00000638138, ENST00000648787, ENST00000652778, ENST00000653002, ENST00000654012, ENST00000654927, ENST00000655581, ENST00000655647, ENST00000656719, ENST00000658426, ENST00000660410, ENST00000663871, ENST00000664259, ENST00000665503, ENST00000666186, ENST00000668443, ENST00000668700, ENST00000668724, ENST00000669682, ENST00000669968, ENST00000670218, ENST00000671673, ENST00000801221, ENST00000801222, ENST00000801223, ENST00000801224, ENST00000801225, ENST00000801226, ENST00000801227, ENST00000801228, ENST00000801229, ENST00000801230, ENST00000801231, ENST00000801232, ENST00000801233, ENST00000801234, ENST00000801235, ENST00000801236, ENST00000801237, ENST00000801238, ENST00000847166, ENST00000847167, ENST00000847168

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000424083 — 3 exons

Exon	Start	End
ENSE00001628312	19749648	19749693
ENSE00001688421	19744031	19744134
ENSE00001778065	19740177	19740238

Expression profiles

Bgee: expression breadth ubiquitous, 158 present calls, max score 94.36.

FANTOM5 (CAGE): breadth broad, TPM avg 2.0416 / max 59.3437, expressed in 788 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
72077	0.9398	490
72076	0.7901	418
72079	0.1969	74
72080	0.1148	40

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	94.36	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.12	gold quality
secondary oocyte	CL:0000655	89.75	gold quality
oocyte	CL:0000023	88.68	gold quality
left lobe of thyroid gland	UBERON:0001120	87.39	gold quality
right lobe of thyroid gland	UBERON:0001119	86.96	gold quality
left coronary artery	UBERON:0001626	86.17	gold quality
thyroid gland	UBERON:0002046	85.81	gold quality
popliteal artery	UBERON:0002250	84.10	gold quality
tibial artery	UBERON:0007610	84.09	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.93	gold quality
coronary artery	UBERON:0001621	83.13	gold quality
aorta	UBERON:0000947	82.12	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	80.71	gold quality
ascending aorta	UBERON:0001496	80.39	gold quality
thoracic aorta	UBERON:0001515	80.06	gold quality
skin of abdomen	UBERON:0001416	79.62	gold quality
right coronary artery	UBERON:0001625	78.89	gold quality
left uterine tube	UBERON:0001303	77.72	gold quality
right atrium auricular region	UBERON:0006631	77.65	gold quality
skin of leg	UBERON:0001511	77.34	gold quality
islet of Langerhans	UBERON:0000006	77.08	gold quality
cardiac atrium	UBERON:0002081	76.70	gold quality
omental fat pad	UBERON:0010414	76.61	gold quality
peritoneum	UBERON:0002358	76.51	gold quality
descending thoracic aorta	UBERON:0002345	76.34	gold quality
right testis	UBERON:0004534	76.17	gold quality
left testis	UBERON:0004533	75.50	gold quality
fallopian tube	UBERON:0003889	75.40	gold quality
adipose tissue of abdominal region	UBERON:0007808	74.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• As a novel regulator, lnc-LBCS plays an important tumor-suppressor role in BCSCs’ self-renewal and chemoresistance, contributing to weak tumorigenesis and enhanced chemosensitivity. The lnc-LBCS-hnRNPK-EZH2-SOX2 regulatory axis may represent a therapeutic target for clinical intervention in chemoresistant bladder cancer. (PMID:30397178)
• Results found the expression of Lnc-LBCS was lower in castration resistant prostate cancer (CRPC) cells lines and tissues. LBCS downregulation was correlated with higher Gleason Score, T stage and poor prognosis of CRPC patients. Lnc-LBCS functions as a novel AR translational regulator that suppresses castration resistance of prostate cancer by interacting with hnRNPK. (PMID:31221168)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.