LNCAROD

Summary

LNCAROD (lncRNA activating regulator of DKK1, HGNC:50913) is a long non-coding RNA gene on chromosome 10q21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50913
Approved symbol	LNCAROD
Name	lncRNA activating regulator of DKK1
Location	10q21.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	lnc-MBL2-4, A-ROD
Ensembl gene	ENSG00000231131
Ensembl biotype	lncRNA
Entrez	101928687
RNAcentral	URS000075CC38 — lncRNA, 1007 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 49 — 49 lncRNA

ENST00000422763, ENST00000435813, ENST00000443523, ENST00000448017, ENST00000647908, ENST00000657963, ENST00000687752, ENST00000691475, ENST00000736176, ENST00000736177, ENST00000736178, ENST00000736179, ENST00000736180, ENST00000736181, ENST00000736182, ENST00000736183, ENST00000736184, ENST00000736185, ENST00000736186, ENST00000736187, ENST00000736188, ENST00000736189, ENST00000736190, ENST00000736191, ENST00000736192, ENST00000736193, ENST00000736194, ENST00000736195, ENST00000736196, ENST00000736197, ENST00000736198, ENST00000736199, ENST00000736200, ENST00000736201, ENST00000736202, ENST00000736203, ENST00000736204, ENST00000736205, ENST00000736206, ENST00000736207, ENST00000736208, ENST00000736209, ENST00000736210, ENST00000736211, ENST00000736212, ENST00000736213, ENST00000736214, ENST00000736215, ENST00000736216

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000422763 — 4 exons

Exon	Start	End
ENSE00001638048	52463268	52463332
ENSE00001685487	52451314	52451517
ENSE00001723463	52454586	52454749
ENSE00001767429	52470397	52470533

Expression profiles

Bgee: expression breadth ubiquitous, 145 present calls, max score 90.78.

FANTOM5 (CAGE): breadth broad, TPM avg 4.0587 / max 204.5524, expressed in 538 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
109395	1.2404	311
109381	0.9815	154
109382	0.8687	159
109379	0.3572	129
109396	0.2560	123
109380	0.1439	86
109378	0.1335	75
109377	0.0594	28
109397	0.0182	6

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.78	gold quality
monocyte	CL:0000576	81.65	gold quality
leukocyte	CL:0000738	79.89	gold quality
bone marrow cell	CL:0002092	69.95	silver quality
sural nerve	UBERON:0015488	65.53	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	62.90	gold quality
ventricular zone	UBERON:0003053	61.42	gold quality
spinal cord	UBERON:0002240	60.84	gold quality
right lobe of liver	UBERON:0001114	60.65	gold quality
gall bladder	UBERON:0002110	59.50	gold quality
vermiform appendix	UBERON:0001154	59.49	gold quality
left coronary artery	UBERON:0001626	56.18	gold quality
ganglionic eminence	UBERON:0004023	55.96	gold quality
left adrenal gland cortex	UBERON:0035825	55.80	gold quality
left adrenal gland	UBERON:0001234	55.75	gold quality
right coronary artery	UBERON:0001625	55.67	gold quality
blood	UBERON:0000178	55.50	gold quality
prefrontal cortex	UBERON:0000451	55.10	gold quality
coronary artery	UBERON:0001621	55.06	gold quality
substantia nigra	UBERON:0002038	55.02	gold quality
descending thoracic aorta	UBERON:0002345	54.74	gold quality
thoracic aorta	UBERON:0001515	54.66	gold quality
ascending aorta	UBERON:0001496	54.25	gold quality
stromal cell of endometrium	CL:0002255	54.16	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	53.84	gold quality
caecum	UBERON:0001153	53.73	gold quality
adrenal gland	UBERON:0002369	53.66	gold quality
adrenal cortex	UBERON:0001235	53.50	gold quality
islet of Langerhans	UBERON:0000006	53.33	gold quality
smooth muscle tissue	UBERON:0001135	53.27	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-180759	yes	2961.99
E-HCAD-35	yes	1564.16
E-ANND-3	no	3.68

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• A-ROD enhances DKK1 transcription via its nascent spliced released form. (PMID:29691407)
• LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma. (PMID:32216017)
• Genetic Association of a Gain-of-Function IFNGR1 Polymorphism and the Intergenic Region LNCAROD/DKK1 With Behcet’s Disease. (PMID:33393726)
• Analysis of lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer. (PMID:35351056)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.