LNCARSR

Summary

LNCARSR (lncRNA regulator of Akt signaling associated with HCC and RCC, HGNC:53864) is a long non-coding RNA gene on chromosome 9q21.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53864
Approved symbol	LNCARSR
Name	lncRNA regulator of Akt signaling associated with HCC and RCC
Location	9q21.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	lnc-TALC
Ensembl gene	ENSG00000233086
Ensembl biotype	lncRNA
Entrez	102723932
RNAcentral	URS00026A271B — lncRNA, 1187 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 20 lncRNA

ENST00000413352, ENST00000424980, ENST00000608561, ENST00000628133, ENST00000656806, ENST00000663687, ENST00000665514, ENST00000666862, ENST00000670754, ENST00000671232, ENST00000834838, ENST00000834839, ENST00000834840, ENST00000834841, ENST00000834842, ENST00000834843, ENST00000834844, ENST00000834845, ENST00000834846, ENST00000834847

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413352 — 2 exons

Exon	Start	End
ENSE00004252673	79532217	79532345
ENSE00004252674	79515643	79518448

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 76.56.

Top tissues by expression

195 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.56	silver quality
right testis	UBERON:0004534	76.02	gold quality
left testis	UBERON:0004533	75.20	gold quality
sperm	CL:0000019	73.55	silver quality
testis	UBERON:0000473	73.01	gold quality
bone marrow cell	CL:0002092	67.16	silver quality
cardiac muscle of right atrium	UBERON:0003379	65.69	gold quality
left ventricle myocardium	UBERON:0006566	64.97	gold quality
tibialis anterior	UBERON:0001385	63.27	silver quality
ileal mucosa	UBERON:0000331	61.72	silver quality
ventricular zone	UBERON:0003053	58.68	silver quality
ganglionic eminence	UBERON:0004023	58.34	silver quality
monocyte	CL:0000576	57.53	gold quality
pancreatic ductal cell	CL:0002079	57.29	silver quality
myocardium	UBERON:0002349	56.23	gold quality
kidney epithelium	UBERON:0004819	55.08	gold quality
deltoid	UBERON:0001476	54.60	gold quality
epithelial cell of pancreas	CL:0000083	54.32	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
prefrontal cortex	UBERON:0000451	52.72	gold quality
calcaneal tendon	UBERON:0003701	52.46	silver quality
islet of Langerhans	UBERON:0000006	52.33	gold quality
adult organism	UBERON:0007023	51.54	gold quality
right lobe of liver	UBERON:0001114	50.64	gold quality
muscle of leg	UBERON:0001383	50.21	gold quality
gastrocnemius	UBERON:0001388	48.84	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	48.83	gold quality
quadriceps femoris	UBERON:0001377	48.28	gold quality
left coronary artery	UBERON:0001626	47.57	gold quality
cardia of stomach	UBERON:0001162	47.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.90

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• Data suggest that lncARSR (long non-coding RNA (lncRNA) activated in renal cell carcinoma (RCC) with sunitinib resistance) may serve as a predictor and a potential therapeutic target for sunitinib resistance. (PMID:27117758)
• lncARSR interacts with Yes-associated protein (YAP) to block its phosphorylation by LATS1, facilitating YAP nuclear translocation. (PMID:27886176)
• High lncARSR expression is associated with liver cancer. (PMID:30391438)
• Genetic variants in a long noncoding RNA related to Sunitinib Resistance predict risk and survival of patients with renal cell carcinoma. (PMID:31038847)
• Long noncoding RNA ARSR is associated with a poor prognosis in patients with colorectal cancer. (PMID:32558022)
• lncARSR sponges miR-34a-5p to promote colorectal cancer invasion and metastasis via hexokinase-1-mediated glycolysis. (PMID:32798250)
• Renal cell carcinoma-derived exosomes deliver lncARSR to induce macrophage polarization and promote tumor progression via STAT3 pathway. (PMID:35637970)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.