LNCBRM

Summary

LNCBRM (lncRNA SMARCA2 (BRM) associated, HGNC:52752) is a long non-coding RNA gene on chromosome 5q11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52752
Approved symbol	LNCBRM
Name	lncRNA SMARCA2 (BRM) associated
Location	5q11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINCR-0003, lncBRM
Ensembl gene	ENSG00000249436
Ensembl biotype	lncRNA
Entrez	100996645
RNAcentral	URS000075A45E — lncRNA, 1321 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000509844, ENST00000513392, ENST00000654759, ENST00000658534, ENST00000660175, ENST00000663255, ENST00000664455, ENST00000667799, ENST00000668787, ENST00000670275, ENST00000670346, ENST00000670663, ENST00000671639, ENST00000718445, ENST00000718446

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000509844 — 2 exons

Exon	Start	End
ENSE00003883690	57616725	57617465
ENSE00003886984	57614141	57614501

Expression profiles

Bgee: expression breadth broad, 88 present calls, max score 87.36.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3087 / max 129.1825, expressed in 37 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
56539	0.1722	36
56540	0.0698	28
56538	0.0667	30

Top tissues by expression

88 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	87.36	gold quality
superior frontal gyrus	UBERON:0002661	87.16	gold quality
prefrontal cortex	UBERON:0000451	86.58	gold quality
frontal cortex	UBERON:0001870	85.46	gold quality
Brodmann (1909) area 9	UBERON:0013540	84.92	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	84.67	gold quality
right frontal lobe	UBERON:0002810	84.13	gold quality
cerebellar hemisphere	UBERON:0002245	83.53	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.19	gold quality
cerebral cortex	UBERON:0000956	80.15	gold quality
primary visual cortex	UBERON:0002436	78.92	gold quality
anterior cingulate cortex	UBERON:0009835	78.67	gold quality
brain	UBERON:0000955	67.67	gold quality
amygdala	UBERON:0001876	65.50	gold quality
temporal lobe	UBERON:0001871	65.37	gold quality
liver	UBERON:0002107	64.32	silver quality
cortical plate	UBERON:0005343	63.94	gold quality
corpus callosum	UBERON:0002336	59.67	gold quality
multicellular organism	UBERON:0000468	56.76	gold quality
Ammon’s horn	UBERON:0001954	56.46	gold quality
right testis	UBERON:0004534	56.20	gold quality
testis	UBERON:0000473	55.22	gold quality
metanephros cortex	UBERON:0010533	54.90	gold quality
lymph node	UBERON:0000029	54.70	gold quality
left testis	UBERON:0004533	54.54	gold quality
cortex of kidney	UBERON:0001225	54.12	gold quality
monocyte	CL:0000576	54.11	gold quality
thoracic mammary gland	UBERON:0005200	53.08	gold quality
kidney	UBERON:0002113	51.15	gold quality
blood	UBERON:0000178	50.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• lncBRM and YAP1 signalling may serve as biomarkers for diagnosis and potential drug targets for hepatocellular carcinoma. (PMID:27905400)
• lncBRM was highly expressed in colorectal cancer and sponged miR-204-3p to modulate the expression of TPT1. (PMID:30563768)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.