LNCOC1

Summary

LNCOC1 (lncRNA associated with ovarian cancer 1, HGNC:53947) is a long non-coding RNA gene on chromosome 8q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53947
Approved symbol	LNCOC1
Name	lncRNA associated with ovarian cancer 1
Location	8q24.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	Lnc-OC1
Ensembl gene	ENSG00000253741
Ensembl biotype	lncRNA
Entrez	100288181
RNAcentral	URS0000759EB7 — lncRNA, 5714 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 13 lncRNA

ENST00000520572, ENST00000654797, ENST00000662059, ENST00000663158, ENST00000665898, ENST00000669349, ENST00000687725, ENST00000689400, ENST00000701145, ENST00000748172, ENST00000748173, ENST00000748174, ENST00000748175

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000520572 — 3 exons

Exon	Start	End
ENSE00002111847	142708315	142708418
ENSE00004090719	142702252	142707579
ENSE00004090725	142726722	142727056

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 76.15.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2018 / max 21.4732, expressed in 508 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
95416	0.9506	448
95417	0.2512	131

Top tissues by expression

221 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	76.15	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.07	gold quality
prefrontal cortex	UBERON:0000451	67.31	gold quality
right frontal lobe	UBERON:0002810	62.87	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	62.78	gold quality
anterior cingulate cortex	UBERON:0009835	62.32	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.95	gold quality
frontal cortex	UBERON:0001870	61.00	gold quality
neocortex	UBERON:0001950	60.75	gold quality
spinal cord	UBERON:0002240	60.73	gold quality
hypothalamus	UBERON:0001898	59.45	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	59.39	gold quality
nucleus accumbens	UBERON:0001882	59.31	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.25	gold quality
muscle of leg	UBERON:0001383	59.12	gold quality
ventricular zone	UBERON:0003053	58.99	silver quality
cortical plate	UBERON:0005343	58.99	gold quality
putamen	UBERON:0001874	58.77	gold quality
caudate nucleus	UBERON:0001873	58.55	gold quality
gastrocnemius	UBERON:0001388	58.18	gold quality
amygdala	UBERON:0001876	57.88	gold quality
substantia nigra	UBERON:0002038	57.64	gold quality
left testis	UBERON:0004533	57.22	gold quality
cerebral cortex	UBERON:0000956	57.16	gold quality
right testis	UBERON:0004534	56.78	gold quality
cerebellar hemisphere	UBERON:0002245	56.51	gold quality
testis	UBERON:0000473	56.50	gold quality
right hemisphere of cerebellum	UBERON:0014890	56.49	gold quality
cerebellar cortex	UBERON:0002129	56.45	gold quality
forebrain	UBERON:0001890	55.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.10

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• rescue experiments demonstrated that the oncogenic function of Lnc-OC1 at least partially depended on suppressing miR-34a and miR-34c. In conclusion, our results suggest that the Lnc-OC1-miR-34a/34c axis may play a pivotal role in ovarian cancer (OC), and may serve as a potential diagnostic biomarker and a powerful therapeutic target for OC (PMID:29576507)
• Downregulation of Lnc-OC1 attenuates the pathogenesis of polycystic ovary syndrome. (PMID:32070768)
• The Correlation Between Helicobacter pylori Infection and Lnc-OC1 Expression in Gastric Cancer Tissues in an Iranian Population. (PMID:32529394)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.