LNCOG

Summary

LNCOG (lncRNA osteogenesis associated, HGNC:53336) is a long non-coding RNA gene on chromosome 12q21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53336
Approved symbol	LNCOG
Name	lncRNA osteogenesis associated
Location	12q21.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-54A9.1, lncRNA-OG
Ensembl gene	ENSG00000257219
Ensembl biotype	lncRNA
Entrez	105369848
RNAcentral	URS0000BC450B — lncRNA, 1943 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000550380, ENST00000553247, ENST00000838955, ENST00000838956, ENST00000838957, ENST00000838958, ENST00000838959, ENST00000838960

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000550380 — 4 exons

Exon	Start	End
ENSE00002331827	76293813	76294005
ENSE00002378676	76292116	76292270
ENSE00004260698	76304474	76305969
ENSE00004260700	76259839	76259981

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 78.87.

FANTOM5 (CAGE): breadth broad, TPM avg 7.0701 / max 349.8625, expressed in 685 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
126946	6.6630	664
126945	0.2672	152
126947	0.1399	68

Top tissues by expression

101 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	78.87	gold quality
omental fat pad	UBERON:0010414	65.68	gold quality
stromal cell of endometrium	CL:0002255	64.66	gold quality
adipose tissue	UBERON:0001013	62.69	gold quality
skeletal muscle tissue	UBERON:0001134	62.25	gold quality
gastrocnemius	UBERON:0001388	60.38	gold quality
subcutaneous adipose tissue	UBERON:0002190	59.97	gold quality
muscle of leg	UBERON:0001383	59.88	gold quality
thoracic mammary gland	UBERON:0005200	59.60	gold quality
hindlimb stylopod muscle	UBERON:0004252	58.54	gold quality
fundus of stomach	UBERON:0001160	57.69	gold quality
myometrium	UBERON:0001296	57.39	gold quality
endometrium	UBERON:0001295	56.93	gold quality
right lung	UBERON:0002167	56.17	gold quality
left coronary artery	UBERON:0001626	55.70	gold quality
tibial nerve	UBERON:0001323	54.04	gold quality
metanephros cortex	UBERON:0010533	53.88	gold quality
heart left ventricle	UBERON:0002084	53.70	gold quality
right adrenal gland cortex	UBERON:0035827	52.77	gold quality
liver	UBERON:0002107	52.52	silver quality
adrenal gland	UBERON:0002369	52.33	gold quality
heart	UBERON:0000948	52.17	gold quality
placenta	UBERON:0001987	52.09	gold quality
right adrenal gland	UBERON:0001233	52.05	gold quality
left adrenal gland	UBERON:0001234	51.89	gold quality
descending thoracic aorta	UBERON:0002345	51.57	gold quality
left adrenal gland cortex	UBERON:0035825	51.36	gold quality
lung	UBERON:0002048	50.91	gold quality
upper lobe of left lung	UBERON:0008952	50.85	gold quality
kidney	UBERON:0002113	50.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.39

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC02407 plays a role in gastric adenocarcinoma through the LINC02407-miR-6845-5p/miR-4455-ADGRD1 pathways, and thus, it may be an important oncogene and has potential value in gastric adenocarcinoma diagnosis and treatment. (PMID:31660034)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.