LNCPRESS1

Summary

LNCPRESS1 (lncRNA p53 regulated and ESC associated 1, HGNC:52746) is a long non-coding RNA gene on chromosome 7q22.1.

Involved in negative regulation of protein localization to chromatin and positive regulation of stem cell population maintenance.

Source: NCBI Gene 101927721 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52746
Approved symbol	LNCPRESS1
Name	lncRNA p53 regulated and ESC associated 1
Location	7q22.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000232301
Ensembl biotype	lncRNA
Entrez	101927721
RNAcentral	URS0000BC450A — lncRNA, 832 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 8 lncRNA, 1 retained_intron

ENST00000429254, ENST00000687754, ENST00000692398, ENST00000718491, ENST00000718492, ENST00000849539, ENST00000849540, ENST00000849541, ENST00000849542

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000429254 — 2 exons

Exon	Start	End
ENSE00001613527	101299558	101299866
ENSE00001768078	101300769	101301346

Expression profiles

Bgee: expression breadth broad, 43 present calls, max score 65.49.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.8943 / max 100.3666, expressed in 74 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
80191	0.8672	74
80190	0.0271	18

Top tissues by expression

49 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
quadriceps femoris	UBERON:0001377	65.49	gold quality
cerebellar vermis	UBERON:0004720	64.61	gold quality
skeletal muscle tissue	UBERON:0001134	60.56	silver quality
bone marrow	UBERON:0002371	60.30	silver quality
lung	UBERON:0002048	58.27	silver quality
thymus	UBERON:0002370	57.65	silver quality
adrenal gland	UBERON:0002369	55.27	gold quality
blood	UBERON:0000178	52.47	silver quality
monocyte	CL:0000576	52.22	silver quality
liver	UBERON:0002107	52.09	silver quality
prefrontal cortex	UBERON:0000451	51.43	gold quality
endometrium	UBERON:0001295	50.21	gold quality
cortex of kidney	UBERON:0001225	48.95	silver quality
right lobe of liver	UBERON:0001114	48.92	silver quality
heart left ventricle	UBERON:0002084	48.77	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	48.56	gold quality
islet of Langerhans	UBERON:0000006	47.89	gold quality
pancreas	UBERON:0001264	46.88	silver quality
gastrocnemius	UBERON:0001388	46.72	silver quality
primary visual cortex	UBERON:0002436	46.12	silver quality
body of pancreas	UBERON:0001150	44.86	silver quality
frontal cortex	UBERON:0001870	44.76	silver quality
adult mammalian kidney	UBERON:0000082	44.32	silver quality
cerebellar hemisphere	UBERON:0002245	44.25	silver quality
heart	UBERON:0000948	43.99	silver quality
prostate gland	UBERON:0002367	43.66	silver quality
thoracic mammary gland	UBERON:0005200	43.62	gold quality
Brodmann (1909) area 9	UBERON:0013540	43.52	silver quality
caudate nucleus	UBERON:0001873	43.30	silver quality
nucleus accumbens	UBERON:0001882	42.26	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• E2F1-induced lncRNA, EMSLR regulates lncRNA LncPRESS1. (PMID:35169159)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.