LNCPTCTS

Summary

LNCPTCTS (lncRNA papillary thyroid carcinoma tumor suppressor, HGNC:56876) is a long non-coding RNA gene on chromosome 16p13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56876
Approved symbol	LNCPTCTS
Name	lncRNA papillary thyroid carcinoma tumor suppressor
Location	16p13.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-616M22.2
Ensembl gene	ENSG00000259910
Ensembl biotype	lncRNA
Entrez	132322117
RNAcentral	URS000059B87E — lncRNA, 476 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000563593

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000563593 — 2 exons

Exon	Start	End
ENSE00002577436	1159548	1159977
ENSE00002593200	1160131	1160176

Expression profiles

Bgee: expression breadth ubiquitous, 110 present calls, max score 83.21.

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pituitary gland	UBERON:0000007	83.21	gold quality
left lobe of thyroid gland	UBERON:0001120	79.88	gold quality
thyroid gland	UBERON:0002046	79.71	gold quality
adenohypophysis	UBERON:0002196	79.23	gold quality
right lobe of thyroid gland	UBERON:0001119	78.31	gold quality
hindlimb stylopod muscle	UBERON:0004252	75.90	gold quality
colonic epithelium	UBERON:0000397	73.26	gold quality
right uterine tube	UBERON:0001302	70.04	gold quality
right atrium auricular region	UBERON:0006631	70.01	gold quality
apex of heart	UBERON:0002098	69.81	gold quality
left adrenal gland cortex	UBERON:0035825	67.34	gold quality
left adrenal gland	UBERON:0001234	67.27	gold quality
adrenal gland	UBERON:0002369	67.06	gold quality
cortical plate	UBERON:0005343	66.87	gold quality
right adrenal gland	UBERON:0001233	66.72	gold quality
adrenal tissue	UBERON:0018303	65.84	gold quality
right adrenal gland cortex	UBERON:0035827	65.42	gold quality
heart	UBERON:0000948	63.62	gold quality
sural nerve	UBERON:0015488	63.62	silver quality
right coronary artery	UBERON:0001625	63.07	gold quality
cortex of kidney	UBERON:0001225	62.44	gold quality
heart left ventricle	UBERON:0002084	61.80	gold quality
tibial artery	UBERON:0007610	60.26	gold quality
popliteal artery	UBERON:0002250	60.24	gold quality
kidney	UBERON:0002113	58.61	gold quality
metanephros cortex	UBERON:0010533	58.24	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	58.09	gold quality
fallopian tube	UBERON:0003889	57.82	gold quality
liver	UBERON:0002107	57.40	gold quality
adult mammalian kidney	UBERON:0000082	57.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Inflammatory cytokine-regulated LNCPTCTS suppresses thyroid cancer progression via enhancing Snail nuclear export. (PMID:37741431)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.