LNCRI

Summary

LNCRI (lncRNA radiation induced regulator of PLK1 and RAD51, HGNC:53790) is a long non-coding RNA gene on chromosome 7p22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53790
Approved symbol	LNCRI
Name	lncRNA radiation induced regulator of PLK1 and RAD51
Location	7p22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	lnc-RI
Ensembl gene	ENSG00000205971
Ensembl biotype	lncRNA
Entrez	401296
RNAcentral	URS00007C2E15 — lncRNA, 1423 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000382528, ENST00000620671, ENST00000649710

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000382528 — 2 exons

Exon	Start	End
ENSE00001492434	1692810	1694085
ENSE00001492435	1694179	1694325

Expression profiles

Bgee: expression breadth broad, 39 present calls, max score 70.22.

Top tissues by expression

39 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	70.22	gold quality
ganglionic eminence	UBERON:0004023	59.45	gold quality
lung	UBERON:0002048	58.00	gold quality
sural nerve	UBERON:0015488	57.38	silver quality
urinary bladder	UBERON:0001255	54.68	gold quality
muscle of leg	UBERON:0001383	52.23	silver quality
stromal cell of endometrium	CL:0002255	51.78	silver quality
monocyte	CL:0000576	49.14	silver quality
blood	UBERON:0000178	49.10	silver quality
Brodmann (1909) area 9	UBERON:0013540	48.95	silver quality
apex of heart	UBERON:0002098	48.20	gold quality
gastrocnemius	UBERON:0001388	47.90	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	47.08	silver quality
prefrontal cortex	UBERON:0000451	46.90	silver quality
kidney	UBERON:0002113	46.65	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	46.50	silver quality
heart	UBERON:0000948	46.45	gold quality
superior frontal gyrus	UBERON:0002661	45.84	silver quality
body of stomach	UBERON:0001161	45.39	silver quality
multicellular organism	UBERON:0000468	45.24	gold quality
tibial artery	UBERON:0007610	44.87	silver quality
right testis	UBERON:0004534	44.85	gold quality
left testis	UBERON:0004533	44.75	gold quality
testis	UBERON:0000473	44.46	gold quality
Ammon’s horn	UBERON:0001954	43.93	silver quality
stomach	UBERON:0000945	43.70	silver quality
heart left ventricle	UBERON:0002084	43.45	silver quality
dorsolateral prefrontal cortex	UBERON:0009834	42.99	silver quality
muscle layer of sigmoid colon	UBERON:0035805	41.51	gold quality
lower esophagus muscularis layer	UBERON:0035833	40.91	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The expression of RAD51 recombinase (RAD51), a key recombinase in the homologous recombination (HR) repair pathway, decreased sharply in long non-coding RNA lnc-RI-depressed cells. (PMID:29216366)
• Long noncoding RNA lnc-RI regulates DNA damage repair and radiation sensitivity of CRC cells through NHEJ pathway. (PMID:32279126)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.