LNCSRLR

Summary

LNCSRLR (lncRNA sorafenib resistance in renal cell carcinoma associated, HGNC:52753) is a long non-coding RNA gene on chromosome 3q24.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52753
Approved symbol	LNCSRLR
Name	lncRNA sorafenib resistance in renal cell carcinoma associated
Location	3q24
Locus type	RNA, long non-coding
Status	Approved
Aliases	lncRNA-SRLR
Ensembl gene	ENSG00000240032
Ensembl biotype	lncRNA
Entrez	109729161
RNAcentral	URS0000074712 — lncRNA, 709 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000490375

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000490375 — 2 exons

Exon	Start	End
ENSE00001890730	146068819	146069185
ENSE00001944293	146066344	146066685

Expression profiles

Bgee: expression breadth ubiquitous, 122 present calls, max score 85.34.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0695 / max 13.9922, expressed in 21 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
44887	0.0695	21

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.34	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.50	gold quality
calcaneal tendon	UBERON:0003701	79.00	gold quality
islet of Langerhans	UBERON:0000006	70.26	gold quality
ventricular zone	UBERON:0003053	64.87	gold quality
ganglionic eminence	UBERON:0004023	64.11	gold quality
smooth muscle tissue	UBERON:0001135	63.78	gold quality
stromal cell of endometrium	CL:0002255	63.08	gold quality
ascending aorta	UBERON:0001496	61.70	gold quality
tibial artery	UBERON:0007610	61.18	gold quality
popliteal artery	UBERON:0002250	61.12	gold quality
thoracic aorta	UBERON:0001515	61.10	gold quality
liver	UBERON:0002107	60.72	gold quality
corpus callosum	UBERON:0002336	60.29	gold quality
gall bladder	UBERON:0002110	59.51	gold quality
pancreas	UBERON:0001264	58.93	gold quality
myometrium	UBERON:0001296	57.35	gold quality
skeletal muscle tissue	UBERON:0001134	56.99	gold quality
left coronary artery	UBERON:0001626	56.99	gold quality
descending thoracic aorta	UBERON:0002345	56.71	gold quality
urinary bladder	UBERON:0001255	56.51	gold quality
vermiform appendix	UBERON:0001154	56.46	gold quality
mucosa of stomach	UBERON:0001199	56.32	gold quality
omental fat pad	UBERON:0010414	56.28	gold quality
right atrium auricular region	UBERON:0006631	56.07	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	56.02	gold quality
thyroid gland	UBERON:0002046	55.92	gold quality
kidney	UBERON:0002113	55.80	gold quality
cortex of kidney	UBERON:0001225	55.78	gold quality
left lobe of thyroid gland	UBERON:0001120	55.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.47

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Upregulation of the lncRNA SRLR in polycystic ovary syndrome regulates cell apoptosis and IL-6 expression. (PMID:31999854)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.