LNCTAM34A

Summary

LNCTAM34A (long non coding transcriptional activator of miR34a, HGNC:52548) is a long non-coding RNA gene on chromosome 1p36.22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52548
Approved symbol	LNCTAM34A
Name	long non coding transcriptional activator of miR34a
Location	1p36.22
Locus type	RNA, long non-coding
Status	Approved
Aliases	GUARDIN, TP53LC18
Ensembl gene	ENSG00000234546
Ensembl biotype	lncRNA
Entrez	102724571
RNAcentral	URS00008E3A18 — lncRNA, 1003 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 28 — 28 lncRNA

ENST00000412639, ENST00000634966, ENST00000635271, ENST00000657715, ENST00000664915, ENST00000665148, ENST00000782997, ENST00000782998, ENST00000782999, ENST00000783000, ENST00000783001, ENST00000783002, ENST00000783003, ENST00000783004, ENST00000783005, ENST00000783006, ENST00000783007, ENST00000783008, ENST00000783009, ENST00000783010, ENST00000783011, ENST00000783012, ENST00000783013, ENST00000783014, ENST00000783015, ENST00000783016, ENST00000783017, ENST00000783018

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412639 — 3 exons

Exon	Start	End
ENSE00001761202	9183633	9183807
ENSE00004156596	9191393	9192507
ENSE00004156625	9181962	9182316

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 95.88.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.3225 / max 23.4705, expressed in 1085 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
494	2.3034	1083
495	0.0191	4

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	95.88	gold quality
thymus	UBERON:0002370	94.08	gold quality
cerebellar vermis	UBERON:0004720	93.28	gold quality
quadriceps femoris	UBERON:0001377	90.52	gold quality
right uterine tube	UBERON:0001302	81.07	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.79	gold quality
right adrenal gland cortex	UBERON:0035827	77.00	gold quality
right adrenal gland	UBERON:0001233	76.61	gold quality
prostate gland	UBERON:0002367	75.92	gold quality
minor salivary gland	UBERON:0001830	75.65	gold quality
left adrenal gland cortex	UBERON:0035825	75.41	gold quality
stromal cell of endometrium	CL:0002255	75.36	gold quality
saliva-secreting gland	UBERON:0001044	75.35	gold quality
left adrenal gland	UBERON:0001234	75.14	gold quality
lower esophagus mucosa	UBERON:0035834	75.03	gold quality
left ovary	UBERON:0002119	74.51	gold quality
ovary	UBERON:0000992	73.58	gold quality
ascending aorta	UBERON:0001496	73.09	gold quality
thoracic aorta	UBERON:0001515	73.07	gold quality
colonic epithelium	UBERON:0000397	72.85	gold quality
adrenal gland	UBERON:0002369	72.83	gold quality
descending thoracic aorta	UBERON:0002345	72.81	gold quality
endocervix	UBERON:0000458	72.54	gold quality
esophagus mucosa	UBERON:0002469	72.51	gold quality
right ovary	UBERON:0002118	72.09	gold quality
gall bladder	UBERON:0002110	71.50	gold quality
urinary bladder	UBERON:0001255	71.28	gold quality
body of pancreas	UBERON:0001150	71.26	gold quality
ectocervix	UBERON:0012249	70.85	gold quality
uterine cervix	UBERON:0000002	70.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.19

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The p53-responsive lncRNA GUARDIN is important for maintaining genomic integrity under steady-state conditions and after exposure to exogenous genotoxic stress. (PMID:29593331)
• LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1alpha-FOXO4-p21-dependent signaling axis. (PMID:32149459)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.