LNCTSI

Summary

LNCTSI (lncRNA TGF-beta/SMAD3 pathway interacting, HGNC:56660) is a long non-coding RNA gene on chromosome 21q22.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56660
Approved symbol	LNCTSI
Name	lncRNA TGF-beta/SMAD3 pathway interacting
Location	21q22.13
Locus type	RNA, long non-coding
Status	Approved
Aliases	AP000695.1, PTAR, lnc-TSI, lnc-UTGF, AP000695.4, lnc-CHAF1B-2, lnc-CHAF1B-3, AP000695.2
Ensembl gene	ENSG00000230479
Ensembl biotype	lncRNA
Entrez	128193292
RNAcentral	URS0002A1DF9B — lncRNA, 2303 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000428667, ENST00000429588, ENST00000454980, ENST00000715798, ENST00000820007, ENST00000820008, ENST00000820009, ENST00000820010, ENST00000820011, ENST00000820012

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000428667 — 3 exons

Exon	Start	End
ENSE00001763882	36531971	36532408
ENSE00001783093	36445628	36446007
ENSE00004027955	36430325	36430412

Expression profiles

Bgee: expression breadth ubiquitous, 115 present calls, max score 75.15.

Top tissues by expression

115 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	75.15	gold quality
muscle of leg	UBERON:0001383	73.11	gold quality
gastrocnemius	UBERON:0001388	72.59	gold quality
stromal cell of endometrium	CL:0002255	71.95	gold quality
colonic epithelium	UBERON:0000397	70.20	silver quality
liver	UBERON:0002107	68.12	gold quality
hindlimb stylopod muscle	UBERON:0004252	66.92	gold quality
right lobe of liver	UBERON:0001114	66.76	gold quality
calcaneal tendon	UBERON:0003701	63.81	gold quality
islet of Langerhans	UBERON:0000006	63.71	gold quality
right coronary artery	UBERON:0001625	62.72	gold quality
bone marrow cell	CL:0002092	61.60	silver quality
subcutaneous adipose tissue	UBERON:0002190	60.64	gold quality
mucosa of stomach	UBERON:0001199	58.91	gold quality
smooth muscle tissue	UBERON:0001135	57.63	gold quality
placenta	UBERON:0001987	57.57	gold quality
ascending aorta	UBERON:0001496	56.86	gold quality
thoracic aorta	UBERON:0001515	56.58	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	56.28	gold quality
adipose tissue	UBERON:0001013	55.09	gold quality
urinary bladder	UBERON:0001255	54.65	gold quality
left coronary artery	UBERON:0001626	54.33	gold quality
cortex of kidney	UBERON:0001225	54.29	gold quality
thoracic mammary gland	UBERON:0005200	53.63	gold quality
tibial artery	UBERON:0007610	53.46	gold quality
popliteal artery	UBERON:0002250	53.44	gold quality
left adrenal gland cortex	UBERON:0035825	53.43	gold quality
monocyte	CL:0000576	52.77	silver quality
vermiform appendix	UBERON:0001154	52.71	gold quality
left adrenal gland	UBERON:0001234	52.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.95

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• lnc-TSI reduced renal fibrogenesis through negative regulation of the TGF-beta/Smad pathway. (PMID:30305452)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.