LOH12CR2

Summary

LOH12CR2 (loss of heterozygosity on chromosome 12, region 2, HGNC:26524) is a long non-coding RNA gene on chromosome 12p13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26524
Approved symbol	LOH12CR2
Name	loss of heterozygosity on chromosome 12, region 2
Location	12p13.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOH2CR12
Ensembl gene	ENSG00000205791
Ensembl biotype	lncRNA
Entrez	503693
RNAcentral	URS000075BAC1 — lncRNA, 1538 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000381800

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000381800 — 2 exons

Exon	Start	End
ENSE00004148746	12355401	12356805
ENSE00004148747	12356928	12357067

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 84.68.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3850 / max 14.8748, expressed in 168 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
129723	0.3850	168

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.68	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.62	gold quality
amygdala	UBERON:0001876	75.62	gold quality
putamen	UBERON:0001874	75.46	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	75.41	gold quality
temporal lobe	UBERON:0001871	75.35	gold quality
nucleus accumbens	UBERON:0001882	75.16	gold quality
substantia nigra	UBERON:0002038	74.79	gold quality
caudate nucleus	UBERON:0001873	74.20	gold quality
prefrontal cortex	UBERON:0000451	73.92	gold quality
Ammon’s horn	UBERON:0001954	73.61	gold quality
anterior cingulate cortex	UBERON:0009835	73.12	gold quality
hypothalamus	UBERON:0001898	72.87	gold quality
frontal cortex	UBERON:0001870	72.55	gold quality
cerebral cortex	UBERON:0000956	72.48	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	71.85	gold quality
right frontal lobe	UBERON:0002810	71.02	gold quality
brain	UBERON:0000955	70.59	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.47	gold quality
bone marrow cell	CL:0002092	70.29	silver quality
cortical plate	UBERON:0005343	70.13	gold quality
primary visual cortex	UBERON:0002436	69.99	gold quality
islet of Langerhans	UBERON:0000006	68.92	gold quality
superior frontal gyrus	UBERON:0002661	67.81	gold quality
ventricular zone	UBERON:0003053	67.37	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.21	gold quality
ganglionic eminence	UBERON:0004023	67.18	gold quality
lower esophagus	UBERON:0013473	67.17	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.15	gold quality
popliteal artery	UBERON:0002250	66.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.21

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.