LOXL1-AS1

Summary

LOXL1-AS1 (LOXL1 antisense RNA 1, HGNC:44169) is a long non-coding RNA gene on chromosome 15q24.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44169
Approved symbol	LOXL1-AS1
Name	LOXL1 antisense RNA 1
Location	15q24.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000261801
Ensembl biotype	lncRNA
OMIM	616800
Entrez	100287616
RNAcentral	URS000075AECF — lncRNA, 2501 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 27 lncRNA

ENST00000562130, ENST00000562739, ENST00000562965, ENST00000564194, ENST00000564963, ENST00000565416, ENST00000565689, ENST00000565756, ENST00000566675, ENST00000567257, ENST00000567644, ENST00000568087, ENST00000568229, ENST00000685373, ENST00000688623, ENST00000702413, ENST00000804490, ENST00000804491, ENST00000804492, ENST00000804493, ENST00000804494, ENST00000804495, ENST00000804496, ENST00000804497, ENST00000804498, ENST00000804499, ENST00000804500

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000562130 — 3 exons

Exon	Start	End
ENSE00002587364	73919155	73919383
ENSE00002609219	73926240	73926342
ENSE00004195856	73919838	73920038

Expression profiles

Bgee: expression breadth ubiquitous, 193 present calls, max score 87.52.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.3063 / max 260.4547, expressed in 1239 samples.

FANTOM5 promoters (13 alternative TSS)

Promoter ID	TPM avg	Samples expressed
150867	2.3129	988
150865	1.4218	545
150862	1.2733	573
150871	0.4124	179
150864	0.2070	118
150863	0.1647	106
150873	0.1500	67
150866	0.1207	44
150868	0.0665	24
150870	0.0652	25

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
descending thoracic aorta	UBERON:0002345	87.52	gold quality
thoracic aorta	UBERON:0001515	87.41	gold quality
ascending aorta	UBERON:0001496	87.36	gold quality
pigmented layer of retina	UBERON:0001782	85.83	gold quality
right coronary artery	UBERON:0001625	85.38	gold quality
aorta	UBERON:0000947	85.02	gold quality
popliteal artery	UBERON:0002250	83.34	gold quality
tibial artery	UBERON:0007610	83.31	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.74	gold quality
left coronary artery	UBERON:0001626	82.50	gold quality
ventricular zone	UBERON:0003053	81.17	gold quality
coronary artery	UBERON:0001621	80.45	gold quality
colonic epithelium	UBERON:0000397	80.11	gold quality
stromal cell of endometrium	CL:0002255	79.48	gold quality
right testis	UBERON:0004534	78.99	gold quality
left testis	UBERON:0004533	78.88	gold quality
corpus epididymis	UBERON:0004359	77.93	gold quality
testis	UBERON:0000473	77.36	gold quality
smooth muscle tissue	UBERON:0001135	77.30	gold quality
lower esophagus	UBERON:0013473	77.25	gold quality
lower esophagus muscularis layer	UBERON:0035833	77.25	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	77.12	gold quality
germinal epithelium of ovary	UBERON:0001304	76.86	gold quality
body of pancreas	UBERON:0001150	76.40	gold quality
palpebral conjunctiva	UBERON:0001812	75.81	gold quality
endocervix	UBERON:0000458	75.65	gold quality
pancreas	UBERON:0001264	75.32	gold quality
prostate gland	UBERON:0002367	74.97	gold quality
ganglionic eminence	UBERON:0004023	74.88	gold quality
thyroid gland	UBERON:0002046	74.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 28)

• LOXL1-AS1 contributes to aggressive biological processes that are related with MES phenotype via NF-kappaB signaling. (PMID:29678575)
• LOXL1-AS1 regulates prostate cancer cell proliferation and cell cycle progression through miR-541-3p and CCND1 (PMID:30278884)
• LOXL1-AS1 expression predicts clinical progression and poor prognosis in osteosarcoma patients and functions as oncogenic lncRNA to regulate cell proliferation, cell cycle, migration, and invasion. (PMID:30944201)
• lncRNA LOXL1-AS1 acts as a ceRNA for miR-324-3p to contribute to cholangiocarcinoma progression via modulation of ATP-binding cassette transporter A1 (PMID:31003776)
• Our results demonstrated that the lncRNALOXL1-AS1/miR-let-7a-5p/EGFR axis significantly affected proliferation, migration, and apoptosis of drug-resistant DU-145 Cells, which may provide us with a potential treatment strategy for drug-resistant prostate cancer (PCa) patients (PMID:31188543)
• LncRNA LOXL1-AS is up-regulated in thoracic aortic aneurysm and regulated proliferation and apoptosis of aortic smooth muscle cells. (PMID:31471532)
• LncRNA LOXL1-AS1 regulates the tumorigenesis and development of lung adenocarcinoma through sponging miR-423-5p and targeting MYBL2. (PMID:31758653)
• LncRNA LOXL1-AS1 inhibited cell proliferation, migration and invasion as well as induced apoptosis in breast cancer via regulating miR-143-3p. (PMID:31841194)
• LncRNA LOXL1-AS1 promotes endometrial cancer progression by sponging miR-28-5p to upregulate RAP1B expression. (PMID:32006897)
• Identification and activity of the functional complex between hnRNPL and the pseudoexfoliation syndrome-associated lncRNA, LOXL1-AS1. (PMID:32037441)
• Non-coding RNA LOXL1-AS1 exhibits oncogenic activity in ovarian cancer via regulation of miR-18b-5p/VMA21 axis. (PMID:32058209)
• Serum lncRNA LOXL1-AS1 is a diagnostic and prognostic marker for epithelial ovarian cancer. (PMID:32449981)
• LOXL1-AS1/miR-515-5p/STAT3 Positive Feedback Loop Facilitates Cell Proliferation and Migration in Atherosclerosis. (PMID:32453072)
• LncRNA LOXL1-AS1 controls osteogenic and adipocytic differentiation of bone marrow mesenchymal stem cells in postmenopausal osteoporosis through regulating the miR-196a-5p/Hmga2 axis. (PMID:32651705)
• LncRNA LOXL1-AS1 is transcriptionally activated by JUND and contributes to osteoarthritis progression via targeting the miR-423-5p/KDM5C axis. (PMID:32679142)
• Up-regulation of long non-coding RNA LOXL1-AS1 functions as an oncogene in cervical squamous cell carcinoma by sponging miR-21. (PMID:32881598)
• Long non-conding RNA LOXL1-AS1 sponges miR-589-5p to up-regulate CBX5 expression in renal cell carcinoma. (PMID:33185692)
• Targeted-regulating of miR-515-5p by LncRNA LOXL1-AS1 on the proliferation and migration of trophoblast cells. (PMID:33278425)
• The Long Noncoding RNA LOXL1-AS1 Promotes the Proliferation, Migration, and Invasion in Hepatocellular Carcinoma. (PMID:33381389)
• [Study of the functional significance of polymorphic loci of the LOXL1 gene associated with glaucoma according to genome-wide studies (in silico analysis)].", trans “Izuchenie funktsional’nogo znacheniya polimorfnykh lokusov gena LOXL1, assotsiirovannykh s glaukomoi po dannym polnogenomnykh issledovanii (analiz in silico). (PMID:34726854)
• Study on the mechanism of LOXL1-AS1/miR-3614-5p/YY1 signal axis in the malignant phenotype regulation of hepatocellular carcinoma. (PMID:34863279)
• LncRNA LOXL1-AS1 inhibits proliferation of PDLSCs and downregulates IL-1beta in periodontitis patients. (PMID:34910833)
• LncRNA LOXL1-AS1 Facilitates the Oncogenic Character in Cervical Cancer by the miR-526b-5p /LYPLA1 Axis. (PMID:34984578)
• Long Non-coding RNA LOXL1-AS1 Facilitates Colorectal Cancer Progression via Regulating miR-1224-5p/miR-761/HK2 Axis. (PMID:35441953)
• LncRNA LOXL1-AS1 promotes proliferation and invasion and inhibits apoptosis in retinoblastoma by regulating the MAPK signaling pathway. (PMID:37273040)
• Lysyl oxidase-like 1-antisense 1 (LOXL1-AS1) lncRNA differentially regulates gene and protein expression, signaling and morphology of human ocular cells. (PMID:37540217)
• LOXL1-AS1 promotes cell proliferation in hepatocellular carcinomathrough miR-1224-5p/ITPRIPL2/AKT axis. (PMID:37715432)
• LOXL1-AS1 inhibits JAK2 ubiquitination and promotes cholangiocarcinoma progression through JAK2/STAT3 signaling. (PMID:38267625)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.