LPP-AS2

Summary

LPP-AS2 (LPP antisense RNA 2, HGNC:27952) is a long non-coding RNA gene on chromosome 3q27.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27952
Approved symbol	LPP-AS2
Name	LPP antisense RNA 2
Location	3q27.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	MYCLo-5, MYCLo-6
Ensembl gene	ENSG00000270959
Ensembl biotype	lncRNA
Entrez	339929
RNAcentral	URS000075CD7C — lncRNA, 2897 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000605573

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000605573 — 1 exons

Exon	Start	End
ENSE00004252105	188151206	188154087

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 69.31.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 1.7183 / max 54.2742, expressed in 1159 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
46027	1.7183	1159

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	69.31	silver quality
right atrium auricular region	UBERON:0006631	68.73	gold quality
sural nerve	UBERON:0015488	68.21	gold quality
cardiac atrium	UBERON:0002081	68.01	gold quality
heart left ventricle	UBERON:0002084	67.97	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	67.92	gold quality
cardiac ventricle	UBERON:0002082	67.28	gold quality
smooth muscle tissue	UBERON:0001135	67.17	gold quality
monocyte	CL:0000576	67.12	gold quality
leukocyte	CL:0000738	67.10	gold quality
heart	UBERON:0000948	66.75	gold quality
descending thoracic aorta	UBERON:0002345	66.41	gold quality
stromal cell of endometrium	CL:0002255	66.14	gold quality
apex of heart	UBERON:0002098	66.06	gold quality
right adrenal gland cortex	UBERON:0035827	66.04	gold quality
right adrenal gland	UBERON:0001233	65.98	gold quality
gall bladder	UBERON:0002110	65.97	gold quality
left adrenal gland	UBERON:0001234	65.92	gold quality
granulocyte	CL:0000094	65.68	gold quality
calcaneal tendon	UBERON:0003701	65.57	gold quality
vermiform appendix	UBERON:0001154	65.44	gold quality
thoracic aorta	UBERON:0001515	65.34	gold quality
left adrenal gland cortex	UBERON:0035825	65.21	gold quality
ascending aorta	UBERON:0001496	65.06	gold quality
aorta	UBERON:0000947	64.88	gold quality
popliteal artery	UBERON:0002250	64.78	gold quality
tibial artery	UBERON:0007610	64.78	gold quality
hindlimb stylopod muscle	UBERON:0004252	64.47	gold quality
adrenal gland	UBERON:0002369	64.13	gold quality
left coronary artery	UBERON:0001626	63.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long non-coding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop. (PMID:32962742)
• Long Non-Coding RNA LPP-AS2 Plays an Anti-Tumor Role in Thyroid Carcinoma by Regulating the miR-132-3p/OLFM1 Axis. (PMID:37199315)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.